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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
REEP4
All Species:
30.3
Human Site:
S222
Identified Species:
60.61
UniProt:
Q9H6H4
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H6H4
NP_079508.2
257
29395
S222
R
E
K
P
L
I
R
S
Q
S
L
R
V
V
K
Chimpanzee
Pan troglodytes
XP_001153858
257
29395
S222
R
E
K
P
L
I
R
S
Q
S
L
R
V
V
K
Rhesus Macaque
Macaca mulatta
XP_001102353
257
29523
S222
R
E
K
P
L
I
R
S
Q
S
L
R
V
V
K
Dog
Lupus familis
XP_543255
413
45887
S378
R
E
K
P
L
N
R
S
Q
S
L
R
V
V
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8K072
257
29672
S222
R
E
K
P
L
G
R
S
Q
S
L
R
V
V
K
Rat
Rattus norvegicus
Q4QQW1
257
29642
S222
R
E
K
P
L
S
R
S
Q
S
L
R
V
V
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508033
254
28447
S219
R
E
K
P
L
A
R
S
Q
S
L
R
V
G
K
Chicken
Gallus gallus
XP_421536
431
48387
R397
M
F
A
Q
R
G
L
R
R
T
Q
S
M
K
S
Frog
Xenopus laevis
NP_001086898
261
29803
S226
P
S
K
S
L
Q
R
S
Q
S
L
R
V
S
K
Zebra Danio
Brachydanio rerio
Q4KMI4
268
30092
A230
D
K
A
P
K
R
I
A
I
T
R
A
A
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10010
229
26592
S195
P
R
P
R
R
R
A
S
S
R
S
R
S
R
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GXE9
258
29531
T222
P
G
R
D
S
A
G
T
F
N
G
D
D
G
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
57.3
N.A.
88.3
88.7
N.A.
74.3
32.2
64.7
50
N.A.
N.A.
N.A.
37.3
N.A.
Protein Similarity:
100
100
98.4
58.5
N.A.
91
91.8
N.A.
82
41
77.3
67.5
N.A.
N.A.
N.A.
57.2
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
86.6
0
66.6
13.3
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
86.6
20
66.6
33.3
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.7
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
17
0
0
17
9
9
0
0
0
9
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
9
0
0
0
0
0
0
0
9
9
0
0
% D
% Glu:
0
59
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
9
0
0
0
0
0
0
9
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
0
17
9
0
0
0
9
0
0
17
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
25
9
0
9
0
0
0
0
0
0
% I
% Lys:
0
9
67
0
9
0
0
0
0
0
0
0
0
17
75
% K
% Leu:
0
0
0
0
67
0
9
0
0
0
67
0
0
0
0
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% M
% Asn:
0
0
0
0
0
9
0
0
0
9
0
0
0
0
0
% N
% Pro:
25
0
9
67
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
9
0
9
0
0
67
0
9
0
0
0
0
% Q
% Arg:
59
9
9
9
17
17
67
9
9
9
9
75
0
9
0
% R
% Ser:
0
9
0
9
9
9
0
75
9
67
9
9
9
9
17
% S
% Thr:
0
0
0
0
0
0
0
9
0
17
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
67
50
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _