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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEM1
All Species:
18.79
Human Site:
S59
Identified Species:
59.05
UniProt:
Q9H790
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H790
NP_073611.1
373
41816
S59
G
K
D
D
K
P
I
S
L
Q
N
W
K
R
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001083573
373
41755
S59
G
K
D
D
K
P
I
S
L
Q
N
W
K
R
G
Dog
Lupus familis
XP_532542
387
43709
S62
G
K
D
D
K
L
I
S
L
P
K
W
K
R
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXP9
373
41605
S59
G
K
D
D
K
P
V
S
L
Q
N
W
K
G
G
Rat
Rattus norvegicus
NP_001101443
373
41691
S59
G
K
D
D
K
P
V
S
L
Q
N
C
K
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_790372
506
57035
L175
T
K
K
A
K
L
D
L
D
L
E
E
E
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001145830
343
38759
R59
R
S
R
L
A
R
F
R
E
R
R
A
L
A
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_200845
413
46955
T91
P
K
T
I
R
S
I
T
L
F
S
K
R
K
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97
81.1
N.A.
83.9
82
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
30.2
Protein Similarity:
100
N.A.
98.1
87.8
N.A.
91.4
90.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
43.2
P-Site Identity:
100
N.A.
100
73.3
N.A.
86.6
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
N.A.
100
73.3
N.A.
93.3
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
27.8
N.A.
27.6
N.A.
N.A.
Protein Similarity:
N.A.
44.2
N.A.
42.1
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
13
13
0
0
0
0
0
0
13
0
13
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% C
% Asp:
0
0
63
63
0
0
13
0
13
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
13
0
13
13
13
0
0
% E
% Phe:
0
0
0
0
0
0
13
0
0
13
0
0
0
0
0
% F
% Gly:
63
0
0
0
0
0
0
0
0
0
0
0
0
13
50
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
13
0
0
50
0
0
0
0
0
0
0
0
% I
% Lys:
0
88
13
0
75
0
0
0
0
0
13
13
63
13
13
% K
% Leu:
0
0
0
13
0
25
0
13
75
13
0
0
13
0
13
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
50
0
0
0
0
% N
% Pro:
13
0
0
0
0
50
0
0
0
13
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
50
0
0
0
0
0
% Q
% Arg:
13
0
13
0
13
13
0
13
0
13
13
0
13
50
13
% R
% Ser:
0
13
0
0
0
13
0
63
0
0
13
0
0
0
0
% S
% Thr:
13
0
13
0
0
0
0
13
0
0
0
0
0
13
0
% T
% Val:
0
0
0
0
0
0
25
0
0
0
0
0
0
0
13
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
50
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _