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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TLE6 All Species: 8.18
Human Site: S72 Identified Species: 15
UniProt: Q9H808 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H808 NP_001137458.1 449 49827 S72 Q E S K A P G S C D P G T D P
Chimpanzee Pan troglodytes XP_512978 572 63399 S195 Q E S K A P A S C D P G T D P
Rhesus Macaque Macaca mulatta XP_001102405 653 69655 A174 K D A P I S P A S I A S S S S
Dog Lupus familis XP_542184 560 61529 P183 L E L R T E D P L A A S P P T
Cat Felis silvestris
Mouse Mus musculus Q9WVB3 581 65097 P202 L C D F K P E P Q P R H R N S
Rat Rattus norvegicus Q07141 748 81316 A269 K D A P I S P A S V A S S S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511869 767 82903 A288 K D A P M S P A S I A S S S S
Chicken Gallus gallus NP_989568 773 83801 A294 K D A P I S P A S I A S S S S
Frog Xenopus laevis O42469 767 82956 S299 A S P N S M T S S S S V S P S
Zebra Danio Brachydanio rerio O13166 761 82441 S251 Y D S D G D K S D D L V V D V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P16371 730 80213 S286 E R L E K P S S S G I K Q E R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O02482 612 65598 A208 R D S T N S V A S S G A S T P
Sea Urchin Strong. purpuratus XP_792326 737 80564 N275 E R E R E R E N A M D K H R A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 77.2 25.5 53.7 N.A. 41.4 24.4 N.A. 23.3 22.7 22.9 23.5 N.A. 21.7 N.A. 23.8 23.2
Protein Similarity: 100 77.9 40.5 62.1 N.A. 52.1 37.4 N.A. 35.9 35.8 36.9 37.3 N.A. 36.5 N.A. 40.6 37.1
P-Site Identity: 100 93.3 0 6.6 N.A. 6.6 0 N.A. 0 0 6.6 26.6 N.A. 13.3 N.A. 13.3 0
P-Site Similarity: 100 93.3 33.3 13.3 N.A. 13.3 33.3 N.A. 33.3 33.3 20 33.3 N.A. 33.3 N.A. 40 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 31 0 16 0 8 39 8 8 39 8 0 0 8 % A
% Cys: 0 8 0 0 0 0 0 0 16 0 0 0 0 0 0 % C
% Asp: 0 47 8 8 0 8 8 0 8 24 8 0 0 24 0 % D
% Glu: 16 24 8 8 8 8 16 0 0 0 0 0 0 8 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 8 0 0 8 8 16 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 0 % H
% Ile: 0 0 0 0 24 0 0 0 0 24 8 0 0 0 0 % I
% Lys: 31 0 0 16 16 0 8 0 0 0 0 16 0 0 0 % K
% Leu: 16 0 16 0 0 0 0 0 8 0 8 0 0 0 0 % L
% Met: 0 0 0 0 8 8 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 8 8 0 0 8 0 0 0 0 0 8 0 % N
% Pro: 0 0 8 31 0 31 31 16 0 8 16 0 8 16 24 % P
% Gln: 16 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % Q
% Arg: 8 16 0 16 0 8 0 0 0 0 8 0 8 8 8 % R
% Ser: 0 8 31 0 8 39 8 39 54 16 8 39 47 31 47 % S
% Thr: 0 0 0 8 8 0 8 0 0 0 0 0 16 8 8 % T
% Val: 0 0 0 0 0 0 8 0 0 8 0 16 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _