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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TLE6 All Species: 7.88
Human Site: Y405 Identified Species: 14.44
UniProt: Q9H808 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H808 NP_001137458.1 449 49827 Y405 M D D F L G V Y S M P A G T K
Chimpanzee Pan troglodytes XP_512978 572 63399 Y528 M D D F L G V Y S M P A G T K
Rhesus Macaque Macaca mulatta XP_001102405 653 69655 W608 K D N L L N A W R T P Y G A S
Dog Lupus familis XP_542184 560 61529 Y516 T D D L L G I Y G M P A G T L
Cat Felis silvestris
Mouse Mus musculus Q9WVB3 581 65097 H537 M G N F I T V H S M P T G A K
Rat Rattus norvegicus Q07141 748 81316 W703 K D N L L N A W R T P Y G A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511869 767 82903 W722 K D N L L N A W R T P Y G A S
Chicken Gallus gallus NP_989568 773 83801 W728 K D N L L N A W R T P Y G A S
Frog Xenopus laevis O42469 767 82956 W722 K D N L L N A W R T P Y G A S
Zebra Danio Brachydanio rerio O13166 761 82441 W716 K D N L L N A W S T P Y G A S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P16371 730 80213 W685 K D N L L N A W R T P Y G A S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O02482 612 65598 W567 K D N A L N A W R T P Y G A S
Sea Urchin Strong. purpuratus XP_792326 737 80564 W692 K D N L L N A W R T P Y G A S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 77.2 25.5 53.7 N.A. 41.4 24.4 N.A. 23.3 22.7 22.9 23.5 N.A. 21.7 N.A. 23.8 23.2
Protein Similarity: 100 77.9 40.5 62.1 N.A. 52.1 37.4 N.A. 35.9 35.8 36.9 37.3 N.A. 36.5 N.A. 40.6 37.1
P-Site Identity: 100 100 26.6 66.6 N.A. 53.3 26.6 N.A. 26.6 26.6 26.6 33.3 N.A. 26.6 N.A. 26.6 26.6
P-Site Similarity: 100 100 40 73.3 N.A. 73.3 40 N.A. 40 40 40 46.6 N.A. 40 N.A. 40 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 70 0 0 0 0 24 0 77 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 93 24 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 24 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 0 0 24 0 0 8 0 0 0 100 0 0 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 8 0 0 0 0 0 0 0 0 % I
% Lys: 70 0 0 0 0 0 0 0 0 0 0 0 0 0 24 % K
% Leu: 0 0 0 70 93 0 0 0 0 0 0 0 0 0 8 % L
% Met: 24 0 0 0 0 0 0 0 0 31 0 0 0 0 0 % M
% Asn: 0 0 77 0 0 70 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 62 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 31 0 0 0 0 0 70 % S
% Thr: 8 0 0 0 0 8 0 0 0 70 0 8 0 24 0 % T
% Val: 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 70 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 24 0 0 0 70 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _