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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL8
All Species:
9.09
Human Site:
S162
Identified Species:
20
UniProt:
Q9H825
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H825
NP_079046
291
33387
S162
H
Y
E
K
S
S
G
S
S
E
G
Q
S
K
T
Chimpanzee
Pan troglodytes
XP_001142282
407
46940
S162
H
Y
E
K
S
S
G
S
S
E
G
Q
S
K
T
Rhesus Macaque
Macaca mulatta
XP_001116039
379
43675
S146
E
E
Q
H
K
C
S
S
K
S
L
E
H
K
T
Dog
Lupus familis
XP_545519
414
47849
S175
Y
N
K
K
R
C
G
S
S
D
G
Q
R
K
A
Cat
Felis silvestris
Mouse
Mus musculus
A2AUU0
281
31651
V152
T
H
C
Q
E
S
F
V
S
P
E
P
G
S
R
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514374
410
46732
V165
K
I
V
S
R
D
G
V
V
H
S
H
S
K
A
Chicken
Gallus gallus
Q5ZHP8
370
42711
P198
I
L
Q
T
N
N
D
P
G
L
F
V
Y
C
C
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A8KBL7
353
40469
P182
I
L
K
T
N
N
D
P
G
L
F
V
Y
C
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q86BS6
325
38113
F162
S
E
P
Q
L
K
V
F
G
C
D
F
S
A
R
Honey Bee
Apis mellifera
XP_624474
332
39379
A179
C
C
D
F
S
A
K
A
L
D
I
L
K
Q
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001175658
397
45417
N170
F
P
E
L
S
S
D
N
A
Q
A
S
A
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.7
34
58.9
N.A.
70.4
N.A.
N.A.
47.5
32.7
N.A.
25.5
N.A.
21.5
27.4
N.A.
23.4
Protein Similarity:
100
71
46.7
64.2
N.A.
79.3
N.A.
N.A.
55.8
47.8
N.A.
40.2
N.A.
40
43.3
N.A.
37.2
P-Site Identity:
100
100
20
46.6
N.A.
13.3
N.A.
N.A.
20
0
N.A.
0
N.A.
6.6
6.6
N.A.
26.6
P-Site Similarity:
100
100
33.3
66.6
N.A.
26.6
N.A.
N.A.
20
20
N.A.
20
N.A.
13.3
40
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
10
10
0
10
0
10
10
19
% A
% Cys:
10
10
10
0
0
19
0
0
0
10
0
0
0
19
19
% C
% Asp:
0
0
10
0
0
10
28
0
0
19
10
0
0
0
0
% D
% Glu:
10
19
28
0
10
0
0
0
0
19
10
10
0
0
10
% E
% Phe:
10
0
0
10
0
0
10
10
0
0
19
10
0
0
0
% F
% Gly:
0
0
0
0
0
0
37
0
28
0
28
0
10
0
0
% G
% His:
19
10
0
10
0
0
0
0
0
10
0
10
10
0
0
% H
% Ile:
19
10
0
0
0
0
0
0
0
0
10
0
0
0
0
% I
% Lys:
10
0
19
28
10
10
10
0
10
0
0
0
10
55
0
% K
% Leu:
0
19
0
10
10
0
0
0
10
19
10
10
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
19
19
0
10
0
0
0
0
0
0
10
% N
% Pro:
0
10
10
0
0
0
0
19
0
10
0
10
0
0
0
% P
% Gln:
0
0
19
19
0
0
0
0
0
10
0
28
0
10
0
% Q
% Arg:
0
0
0
0
19
0
0
0
0
0
0
0
10
0
19
% R
% Ser:
10
0
0
10
37
37
10
37
37
10
10
10
37
10
0
% S
% Thr:
10
0
0
19
0
0
0
0
0
0
0
0
0
0
28
% T
% Val:
0
0
10
0
0
0
10
19
10
0
0
19
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
19
0
0
0
0
0
0
0
0
0
0
19
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _