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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL8
All Species:
12.12
Human Site:
S174
Identified Species:
26.67
UniProt:
Q9H825
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H825
NP_079046
291
33387
S174
S
K
T
E
S
D
F
S
N
L
D
S
E
K
H
Chimpanzee
Pan troglodytes
XP_001142282
407
46940
S174
S
K
T
E
S
D
F
S
N
L
D
S
E
K
H
Rhesus Macaque
Macaca mulatta
XP_001116039
379
43675
V158
H
K
T
E
T
P
P
V
E
E
N
V
T
Q
K
Dog
Lupus familis
XP_545519
414
47849
S187
R
K
A
G
S
H
F
S
N
L
D
S
K
E
H
Cat
Felis silvestris
Mouse
Mus musculus
A2AUU0
281
31651
P164
G
S
R
G
R
S
A
P
D
P
D
L
E
E
Y
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514374
410
46732
A177
S
K
A
G
S
V
G
A
F
Q
C
A
E
E
S
Chicken
Gallus gallus
Q5ZHP8
370
42711
T210
Y
C
C
D
F
S
T
T
A
V
D
L
V
Q
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A8KBL7
353
40469
T194
Y
C
C
D
F
S
S
T
A
V
D
L
V
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q86BS6
325
38113
L174
S
A
R
A
I
E
I
L
R
S
Q
R
Q
F
D
Honey Bee
Apis mellifera
XP_624474
332
39379
T191
K
Q
N
S
A
Y
D
T
S
R
C
K
A
F
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001175658
397
45417
R182
A
K
E
C
S
S
E
R
G
A
S
Q
E
T
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.7
34
58.9
N.A.
70.4
N.A.
N.A.
47.5
32.7
N.A.
25.5
N.A.
21.5
27.4
N.A.
23.4
Protein Similarity:
100
71
46.7
64.2
N.A.
79.3
N.A.
N.A.
55.8
47.8
N.A.
40.2
N.A.
40
43.3
N.A.
37.2
P-Site Identity:
100
100
20
60
N.A.
13.3
N.A.
N.A.
26.6
6.6
N.A.
13.3
N.A.
6.6
0
N.A.
20
P-Site Similarity:
100
100
40
73.3
N.A.
33.3
N.A.
N.A.
46.6
33.3
N.A.
33.3
N.A.
20
26.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
19
10
10
0
10
10
19
10
0
10
10
0
0
% A
% Cys:
0
19
19
10
0
0
0
0
0
0
19
0
0
0
0
% C
% Asp:
0
0
0
19
0
19
10
0
10
0
55
0
0
0
10
% D
% Glu:
0
0
10
28
0
10
10
0
10
10
0
0
46
28
0
% E
% Phe:
0
0
0
0
19
0
28
0
10
0
0
0
0
19
0
% F
% Gly:
10
0
0
28
0
0
10
0
10
0
0
0
0
0
0
% G
% His:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
28
% H
% Ile:
0
0
0
0
10
0
10
0
0
0
0
0
0
0
10
% I
% Lys:
10
55
0
0
0
0
0
0
0
0
0
10
10
28
10
% K
% Leu:
0
0
0
0
0
0
0
10
0
28
0
28
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
28
0
10
0
0
0
0
% N
% Pro:
0
0
0
0
0
10
10
10
0
10
0
0
0
0
0
% P
% Gln:
0
10
0
0
0
0
0
0
0
10
10
10
10
19
0
% Q
% Arg:
10
0
19
0
10
0
0
10
10
10
0
10
0
0
0
% R
% Ser:
37
10
0
10
46
37
10
28
10
10
10
28
0
0
37
% S
% Thr:
0
0
28
0
10
0
10
28
0
0
0
0
10
10
0
% T
% Val:
0
0
0
0
0
10
0
10
0
19
0
10
19
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
19
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _