KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL8
All Species:
9.7
Human Site:
S221
Identified Species:
21.33
UniProt:
Q9H825
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H825
NP_079046
291
33387
S221
I
L
N
T
L
E
N
S
P
E
S
F
L
Y
C
Chimpanzee
Pan troglodytes
XP_001142282
407
46940
S221
I
L
N
T
L
Q
N
S
P
E
S
F
L
Y
C
Rhesus Macaque
Macaca mulatta
XP_001116039
379
43675
D205
P
I
L
Q
T
N
N
D
P
G
L
F
V
Y
C
Dog
Lupus familis
XP_545519
414
47849
A234
I
L
N
T
L
Q
D
A
P
E
S
F
L
Y
C
Cat
Felis silvestris
Mouse
Mus musculus
A2AUU0
281
31651
I211
I
L
N
T
L
Q
N
I
P
G
S
F
L
Y
C
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514374
410
46732
T224
I
L
N
I
L
N
K
T
P
G
T
F
L
Y
C
Chicken
Gallus gallus
Q5ZHP8
370
42711
S257
V
I
L
I
F
V
L
S
A
I
L
P
E
K
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A8KBL7
353
40469
S241
I
V
L
I
F
V
L
S
A
L
H
P
E
K
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q86BS6
325
38113
K221
V
L
S
A
I
E
P
K
K
M
Q
R
V
L
D
Honey Bee
Apis mellifera
XP_624474
332
39379
Q238
K
M
K
H
I
I
E
Q
I
H
K
Y
L
K
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001175658
397
45417
D229
P
I
L
Q
T
N
A
D
P
G
L
F
V
Y
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.7
34
58.9
N.A.
70.4
N.A.
N.A.
47.5
32.7
N.A.
25.5
N.A.
21.5
27.4
N.A.
23.4
Protein Similarity:
100
71
46.7
64.2
N.A.
79.3
N.A.
N.A.
55.8
47.8
N.A.
40.2
N.A.
40
43.3
N.A.
37.2
P-Site Identity:
100
93.3
33.3
80
N.A.
80
N.A.
N.A.
60
6.6
N.A.
13.3
N.A.
13.3
6.6
N.A.
20
P-Site Similarity:
100
100
46.6
100
N.A.
86.6
N.A.
N.A.
73.3
20
N.A.
20
N.A.
40
26.6
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
10
10
19
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
55
% C
% Asp:
0
0
0
0
0
0
10
19
0
0
0
0
0
0
10
% D
% Glu:
0
0
0
0
0
19
10
0
0
28
0
0
19
0
0
% E
% Phe:
0
0
0
0
19
0
0
0
0
0
0
64
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
37
0
0
0
0
10
% G
% His:
0
0
0
10
0
0
0
0
0
10
10
0
0
0
0
% H
% Ile:
55
28
0
28
19
10
0
10
10
10
0
0
0
0
0
% I
% Lys:
10
0
10
0
0
0
10
10
10
0
10
0
0
28
0
% K
% Leu:
0
55
37
0
46
0
19
0
0
10
28
0
55
10
0
% L
% Met:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
19
% M
% Asn:
0
0
46
0
0
28
37
0
0
0
0
0
0
0
0
% N
% Pro:
19
0
0
0
0
0
10
0
64
0
0
19
0
0
0
% P
% Gln:
0
0
0
19
0
28
0
10
0
0
10
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% R
% Ser:
0
0
10
0
0
0
0
37
0
0
37
0
0
0
10
% S
% Thr:
0
0
0
37
19
0
0
10
0
0
10
0
0
0
0
% T
% Val:
19
10
0
0
0
19
0
0
0
0
0
0
28
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
64
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _