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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL8
All Species:
11.21
Human Site:
T135
Identified Species:
24.67
UniProt:
Q9H825
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H825
NP_079046
291
33387
T135
S
S
W
D
H
V
K
T
S
A
T
N
R
F
S
Chimpanzee
Pan troglodytes
XP_001142282
407
46940
T135
S
S
W
D
H
V
K
T
S
A
T
N
C
F
S
Rhesus Macaque
Macaca mulatta
XP_001116039
379
43675
N119
L
K
D
W
F
L
E
N
K
R
S
E
V
P
E
Dog
Lupus familis
XP_545519
414
47849
T148
L
S
W
D
H
A
K
T
S
A
A
N
G
F
S
Cat
Felis silvestris
Mouse
Mus musculus
A2AUU0
281
31651
V125
N
Q
N
T
K
E
K
V
G
E
S
S
W
D
Q
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514374
410
46732
A138
N
H
V
N
T
N
G
A
D
H
F
S
K
V
P
Chicken
Gallus gallus
Q5ZHP8
370
42711
S171
S
Y
E
D
Y
P
G
S
S
A
S
Y
R
I
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A8KBL7
353
40469
A155
T
H
D
E
F
P
G
A
S
A
S
Y
R
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q86BS6
325
38113
S135
S
A
V
L
Q
P
R
S
I
F
E
L
G
C
G
Honey Bee
Apis mellifera
XP_624474
332
39379
V152
I
L
E
I
G
C
G
V
G
N
T
V
F
P
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001175658
397
45417
E143
D
A
D
R
Y
W
N
E
F
Y
S
L
H
Q
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.7
34
58.9
N.A.
70.4
N.A.
N.A.
47.5
32.7
N.A.
25.5
N.A.
21.5
27.4
N.A.
23.4
Protein Similarity:
100
71
46.7
64.2
N.A.
79.3
N.A.
N.A.
55.8
47.8
N.A.
40.2
N.A.
40
43.3
N.A.
37.2
P-Site Identity:
100
93.3
0
73.3
N.A.
6.6
N.A.
N.A.
0
33.3
N.A.
20
N.A.
6.6
6.6
N.A.
0
P-Site Similarity:
100
93.3
20
73.3
N.A.
26.6
N.A.
N.A.
26.6
53.3
N.A.
40
N.A.
26.6
6.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
0
0
0
10
0
19
0
46
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
10
10
0
% C
% Asp:
10
0
28
37
0
0
0
0
10
0
0
0
0
10
0
% D
% Glu:
0
0
19
10
0
10
10
10
0
10
10
10
0
0
10
% E
% Phe:
0
0
0
0
19
0
0
0
10
10
10
0
10
28
0
% F
% Gly:
0
0
0
0
10
0
37
0
19
0
0
0
19
0
10
% G
% His:
0
19
0
0
28
0
0
0
0
10
0
0
10
0
10
% H
% Ile:
10
0
0
10
0
0
0
0
10
0
0
0
0
19
10
% I
% Lys:
0
10
0
0
10
0
37
0
10
0
0
0
10
0
0
% K
% Leu:
19
10
0
10
0
10
0
0
0
0
0
19
0
0
19
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
19
0
10
10
0
10
10
10
0
10
0
28
0
0
0
% N
% Pro:
0
0
0
0
0
28
0
0
0
0
0
0
0
19
10
% P
% Gln:
0
10
0
0
10
0
0
0
0
0
0
0
0
10
10
% Q
% Arg:
0
0
0
10
0
0
10
0
0
10
0
0
28
0
0
% R
% Ser:
37
28
0
0
0
0
0
19
46
0
46
19
0
0
28
% S
% Thr:
10
0
0
10
10
0
0
28
0
0
28
0
0
0
0
% T
% Val:
0
0
19
0
0
19
0
19
0
0
0
10
10
10
0
% V
% Trp:
0
0
28
10
0
10
0
0
0
0
0
0
10
0
0
% W
% Tyr:
0
10
0
0
19
0
0
0
0
10
0
19
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _