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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL8
All Species:
12.42
Human Site:
T138
Identified Species:
27.33
UniProt:
Q9H825
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H825
NP_079046
291
33387
T138
D
H
V
K
T
S
A
T
N
R
F
S
R
M
H
Chimpanzee
Pan troglodytes
XP_001142282
407
46940
T138
D
H
V
K
T
S
A
T
N
C
F
S
R
M
H
Rhesus Macaque
Macaca mulatta
XP_001116039
379
43675
S122
W
F
L
E
N
K
R
S
E
V
P
E
C
R
N
Dog
Lupus familis
XP_545519
414
47849
A151
D
H
A
K
T
S
A
A
N
G
F
S
R
M
H
Cat
Felis silvestris
Mouse
Mus musculus
A2AUU0
281
31651
S128
T
K
E
K
V
G
E
S
S
W
D
Q
V
G
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514374
410
46732
F141
N
T
N
G
A
D
H
F
S
K
V
P
P
P
A
Chicken
Gallus gallus
Q5ZHP8
370
42711
S174
D
Y
P
G
S
S
A
S
Y
R
I
L
E
V
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A8KBL7
353
40469
S158
E
F
P
G
A
S
A
S
Y
R
I
L
E
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q86BS6
325
38113
E138
L
Q
P
R
S
I
F
E
L
G
C
G
V
G
N
Honey Bee
Apis mellifera
XP_624474
332
39379
T155
I
G
C
G
V
G
N
T
V
F
P
I
L
L
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001175658
397
45417
S146
R
Y
W
N
E
F
Y
S
L
H
Q
H
K
F
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.7
34
58.9
N.A.
70.4
N.A.
N.A.
47.5
32.7
N.A.
25.5
N.A.
21.5
27.4
N.A.
23.4
Protein Similarity:
100
71
46.7
64.2
N.A.
79.3
N.A.
N.A.
55.8
47.8
N.A.
40.2
N.A.
40
43.3
N.A.
37.2
P-Site Identity:
100
93.3
0
80
N.A.
6.6
N.A.
N.A.
0
26.6
N.A.
20
N.A.
0
6.6
N.A.
0
P-Site Similarity:
100
93.3
26.6
80
N.A.
20
N.A.
N.A.
20
53.3
N.A.
40
N.A.
20
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
19
0
46
10
0
0
0
0
0
0
10
% A
% Cys:
0
0
10
0
0
0
0
0
0
10
10
0
10
0
0
% C
% Asp:
37
0
0
0
0
10
0
0
0
0
10
0
0
0
0
% D
% Glu:
10
0
10
10
10
0
10
10
10
0
0
10
19
0
0
% E
% Phe:
0
19
0
0
0
10
10
10
0
10
28
0
0
10
10
% F
% Gly:
0
10
0
37
0
19
0
0
0
19
0
10
0
19
19
% G
% His:
0
28
0
0
0
0
10
0
0
10
0
10
0
0
28
% H
% Ile:
10
0
0
0
0
10
0
0
0
0
19
10
0
0
0
% I
% Lys:
0
10
0
37
0
10
0
0
0
10
0
0
10
0
0
% K
% Leu:
10
0
10
0
0
0
0
0
19
0
0
19
10
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
28
0
% M
% Asn:
10
0
10
10
10
0
10
0
28
0
0
0
0
0
19
% N
% Pro:
0
0
28
0
0
0
0
0
0
0
19
10
10
10
0
% P
% Gln:
0
10
0
0
0
0
0
0
0
0
10
10
0
0
0
% Q
% Arg:
10
0
0
10
0
0
10
0
0
28
0
0
28
10
0
% R
% Ser:
0
0
0
0
19
46
0
46
19
0
0
28
0
0
10
% S
% Thr:
10
10
0
0
28
0
0
28
0
0
0
0
0
0
0
% T
% Val:
0
0
19
0
19
0
0
0
10
10
10
0
19
19
0
% V
% Trp:
10
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
19
0
0
0
0
10
0
19
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _