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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL8
All Species:
22.73
Human Site:
Y227
Identified Species:
50
UniProt:
Q9H825
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H825
NP_079046
291
33387
Y227
N
S
P
E
S
F
L
Y
C
C
D
F
A
S
G
Chimpanzee
Pan troglodytes
XP_001142282
407
46940
Y227
N
S
P
E
S
F
L
Y
C
C
D
F
A
S
G
Rhesus Macaque
Macaca mulatta
XP_001116039
379
43675
Y211
N
D
P
G
L
F
V
Y
C
C
D
F
S
S
T
Dog
Lupus familis
XP_545519
414
47849
Y240
D
A
P
E
S
F
L
Y
C
C
D
F
A
S
G
Cat
Felis silvestris
Mouse
Mus musculus
A2AUU0
281
31651
Y217
N
I
P
G
S
F
L
Y
C
C
D
F
A
S
E
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514374
410
46732
Y230
K
T
P
G
T
F
L
Y
C
C
D
F
A
S
G
Chicken
Gallus gallus
Q5ZHP8
370
42711
K263
L
S
A
I
L
P
E
K
M
Q
C
V
I
N
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A8KBL7
353
40469
K247
L
S
A
L
H
P
E
K
M
Q
K
S
I
N
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q86BS6
325
38113
L227
P
K
K
M
Q
R
V
L
D
N
C
Y
R
Y
L
Honey Bee
Apis mellifera
XP_624474
332
39379
K244
E
Q
I
H
K
Y
L
K
S
G
G
L
V
L
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001175658
397
45417
Y235
A
D
P
G
L
F
V
Y
G
C
D
F
S
S
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.7
34
58.9
N.A.
70.4
N.A.
N.A.
47.5
32.7
N.A.
25.5
N.A.
21.5
27.4
N.A.
23.4
Protein Similarity:
100
71
46.7
64.2
N.A.
79.3
N.A.
N.A.
55.8
47.8
N.A.
40.2
N.A.
40
43.3
N.A.
37.2
P-Site Identity:
100
100
60
86.6
N.A.
80
N.A.
N.A.
73.3
6.6
N.A.
6.6
N.A.
0
6.6
N.A.
46.6
P-Site Similarity:
100
100
73.3
100
N.A.
80
N.A.
N.A.
86.6
13.3
N.A.
13.3
N.A.
13.3
13.3
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
19
0
0
0
0
0
0
0
0
0
46
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
55
64
19
0
0
0
0
% C
% Asp:
10
19
0
0
0
0
0
0
10
0
64
0
0
0
0
% D
% Glu:
10
0
0
28
0
0
19
0
0
0
0
0
0
0
10
% E
% Phe:
0
0
0
0
0
64
0
0
0
0
0
64
0
0
10
% F
% Gly:
0
0
0
37
0
0
0
0
10
10
10
0
0
0
37
% G
% His:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
10
10
0
0
0
0
0
0
0
0
19
0
0
% I
% Lys:
10
10
10
0
10
0
0
28
0
0
10
0
0
0
10
% K
% Leu:
19
0
0
10
28
0
55
10
0
0
0
10
0
10
10
% L
% Met:
0
0
0
10
0
0
0
0
19
0
0
0
0
0
0
% M
% Asn:
37
0
0
0
0
0
0
0
0
10
0
0
0
19
0
% N
% Pro:
10
0
64
0
0
19
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
10
0
0
10
0
0
0
0
19
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
10
0
0
0
0
0
0
10
0
10
% R
% Ser:
0
37
0
0
37
0
0
0
10
0
0
10
19
64
0
% S
% Thr:
0
10
0
0
10
0
0
0
0
0
0
0
0
0
10
% T
% Val:
0
0
0
0
0
0
28
0
0
0
0
10
10
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
64
0
0
0
10
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _