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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEKHF2
All Species:
13.64
Human Site:
S239
Identified Species:
27.27
UniProt:
Q9H8W4
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H8W4
NP_078889.1
249
27798
S239
K
S
P
L
N
D
M
S
D
D
D
D
D
D
D
Chimpanzee
Pan troglodytes
XP_512558
279
31146
C239
A
H
L
A
G
P
I
C
G
A
S
S
G
D
D
Rhesus Macaque
Macaca mulatta
XP_001084522
279
31261
C239
A
H
L
T
R
P
I
C
G
A
S
S
G
D
D
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q91WB4
249
27736
S239
K
S
P
L
N
D
A
S
D
D
D
D
D
D
D
Rat
Rattus norvegicus
Q68FU1
279
31422
C239
T
H
L
G
S
T
M
C
G
A
S
S
G
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510746
249
27749
S239
K
S
P
L
N
N
T
S
D
D
D
D
D
D
S
Chicken
Gallus gallus
Q5ZLY5
249
27697
S239
K
S
S
L
N
D
A
S
D
D
D
D
D
E
D
Frog
Xenopus laevis
NP_001091185
248
27817
D239
K
F
K
N
N
L
S
D
D
D
D
D
E
D
S
Zebra Danio
Brachydanio rerio
Q7ZUV1
247
27424
I236
S
D
F
G
S
N
N
I
S
D
D
D
D
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624027
268
29804
S239
Q
R
N
S
A
D
S
S
G
G
D
S
S
G
D
Nematode Worm
Caenorhab. elegans
P34657
266
30169
E239
E
D
S
S
S
D
S
E
D
E
V
N
G
S
G
Sea Urchin
Strong. purpuratus
XP_783303
377
42354
D349
D
Q
D
S
D
D
D
D
D
D
D
E
D
I
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
50.5
50.5
N.A.
N.A.
97.5
48
N.A.
93.1
94.7
85.1
84.3
N.A.
N.A.
61.5
54.1
41.1
Protein Similarity:
100
65.2
65.2
N.A.
N.A.
98.3
63
N.A.
97.1
96.3
95.1
91.5
N.A.
N.A.
72.3
66.1
50.1
P-Site Identity:
100
13.3
13.3
N.A.
N.A.
93.3
20
N.A.
80
80
46.6
40
N.A.
N.A.
26.6
13.3
40
P-Site Similarity:
100
20
20
N.A.
N.A.
93.3
26.6
N.A.
86.6
86.6
53.3
53.3
N.A.
N.A.
33.3
40
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
0
9
9
0
17
0
0
25
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
25
0
0
0
0
0
0
0
% C
% Asp:
9
17
9
0
9
50
9
17
59
59
67
50
50
67
75
% D
% Glu:
9
0
0
0
0
0
0
9
0
9
0
9
9
9
0
% E
% Phe:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
17
9
0
0
0
34
9
0
0
34
9
9
% G
% His:
0
25
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
17
9
0
0
0
0
0
9
0
% I
% Lys:
42
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
25
34
0
9
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
17
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
9
42
17
9
0
0
0
0
9
0
0
0
% N
% Pro:
0
0
25
0
0
17
0
0
0
0
0
0
0
0
0
% P
% Gln:
9
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
0
0
9
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
9
34
17
25
25
0
25
42
9
0
25
34
9
9
17
% S
% Thr:
9
0
0
9
0
9
9
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _