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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEKHF2
All Species:
17.22
Human Site:
S248
Identified Species:
34.44
UniProt:
Q9H8W4
Number Species:
11
Phosphosite Substitution
Charge Score:
0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H8W4
NP_078889.1
249
27798
S248
D
D
D
D
D
D
S
S
D
_
_
_
_
_
_
Chimpanzee
Pan troglodytes
XP_512558
279
31146
D248
A
S
S
G
D
D
D
D
S
D
E
D
K
E
G
Rhesus Macaque
Macaca mulatta
XP_001084522
279
31261
D248
A
S
S
G
D
D
D
D
S
D
E
D
K
E
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q91WB4
249
27736
S248
D
D
D
D
D
D
S
S
D
_
_
_
_
_
_
Rat
Rattus norvegicus
Q68FU1
279
31422
D248
A
S
S
G
D
D
D
D
S
D
E
D
R
E
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510746
249
27749
S248
D
D
D
D
D
S
S
S
D
_
_
_
_
_
_
Chicken
Gallus gallus
Q5ZLY5
249
27697
S248
D
D
D
D
E
D
S
S
D
_
_
_
_
_
_
Frog
Xenopus laevis
NP_001091185
248
27817
Zebra Danio
Brachydanio rerio
Q7ZUV1
247
27424
S245
D
D
D
D
D
D
D
S
S
D
_
_
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624027
268
29804
D248
G
D
S
S
G
D
D
D
D
G
N
K
E
E
N
Nematode Worm
Caenorhab. elegans
P34657
266
30169
S248
E
V
N
G
S
G
R
S
S
N
E
S
R
P
T
Sea Urchin
Strong. purpuratus
XP_783303
377
42354
I358
D
D
E
D
I
D
A
I
T
R
N
T
P
A
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
50.5
50.5
N.A.
N.A.
97.5
48
N.A.
93.1
94.7
85.1
84.3
N.A.
N.A.
61.5
54.1
41.1
Protein Similarity:
100
65.2
65.2
N.A.
N.A.
98.3
63
N.A.
97.1
96.3
95.1
91.5
N.A.
N.A.
72.3
66.1
50.1
P-Site Identity:
100
13.3
13.3
N.A.
N.A.
100
13.3
N.A.
88.8
88.8
0
70
N.A.
N.A.
20
6.6
26.6
P-Site Similarity:
100
20
20
N.A.
N.A.
100
20
N.A.
88.8
100
0
70
N.A.
N.A.
26.6
20
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
0
0
0
0
0
9
0
0
0
0
0
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
50
59
42
50
59
75
42
34
42
34
0
25
0
0
0
% D
% Glu:
9
0
9
0
9
0
0
0
0
0
34
0
9
34
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
34
9
9
0
0
0
9
0
0
0
0
25
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
0
9
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
9
17
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
0
0
9
17
0
0
0
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
9
9
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
9
0
0
9
0
0
17
0
0
% R
% Ser:
0
25
34
9
9
9
34
50
42
0
0
9
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
9
% T
% Val:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
34
42
42
42
42
42
% _