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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD2L
All Species:
17.88
Human Site:
S15
Identified Species:
35.76
UniProt:
Q9H903
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H903
NP_001138450.1
289
31285
S15
E
I
Q
R
G
V
E
S
W
V
S
L
G
N
R
Chimpanzee
Pan troglodytes
XP_517226
379
40691
S105
E
I
Q
R
D
V
E
S
W
V
S
L
G
N
R
Rhesus Macaque
Macaca mulatta
XP_001091218
502
54417
S228
E
I
Q
R
G
V
E
S
W
V
S
L
G
N
R
Dog
Lupus familis
XP_539316
310
33584
S36
E
I
Q
R
G
V
E
S
W
I
S
L
G
N
R
Cat
Felis silvestris
Mouse
Mus musculus
P18155
350
37844
E59
E
V
Q
Q
E
V
E
E
W
V
A
S
G
N
K
Rat
Rattus norvegicus
NP_001100681
338
36408
S64
E
L
Q
Q
G
V
E
S
W
L
A
L
G
N
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511115
253
27145
Chicken
Gallus gallus
Q5ZKA5
337
36393
Q54
E
A
R
H
E
V
E
Q
W
V
A
A
G
N
K
Frog
Xenopus laevis
NP_001085223
335
36310
Q52
E
A
R
H
D
V
E
Q
W
V
A
A
G
N
K
Zebra Danio
Brachydanio rerio
NP_001002181
338
36917
E52
E
A
R
D
D
V
E
E
W
V
S
A
G
N
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q04448
309
33532
G30
Q
L
A
H
E
L
K
G
M
E
A
A
G
Y
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793717
336
36041
E51
E
I
R
E
E
T
D
E
W
I
A
Q
G
N
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
75.7
56.5
90.3
N.A.
62.5
78.6
N.A.
59.1
62.6
64.1
63.6
N.A.
52
N.A.
N.A.
53.5
Protein Similarity:
100
75.9
57.1
92.2
N.A.
72.8
83.1
N.A.
71.6
74.7
76.7
75.4
N.A.
66
N.A.
N.A.
66.6
P-Site Identity:
100
93.3
100
93.3
N.A.
53.3
73.3
N.A.
0
46.6
46.6
60
N.A.
6.6
N.A.
N.A.
40
P-Site Similarity:
100
93.3
100
100
N.A.
80
100
N.A.
0
66.6
66.6
66.6
N.A.
40
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
25
9
0
0
0
0
0
0
0
50
34
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
25
0
9
0
0
0
0
0
0
0
0
% D
% Glu:
84
0
0
9
34
0
75
25
0
9
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
34
0
0
9
0
0
0
0
92
0
0
% G
% His:
0
0
0
25
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
42
0
0
0
0
0
0
0
17
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
25
% K
% Leu:
0
17
0
0
0
9
0
0
0
9
0
42
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
84
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% P
% Gln:
9
0
50
17
0
0
0
17
0
0
0
9
0
0
0
% Q
% Arg:
0
0
34
34
0
0
0
0
0
0
0
0
0
0
59
% R
% Ser:
0
0
0
0
0
0
0
42
0
0
42
9
0
0
0
% S
% Thr:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% T
% Val:
0
9
0
0
0
75
0
0
0
59
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
84
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _