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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD2L
All Species:
42.42
Human Site:
S37
Identified Species:
84.85
UniProt:
Q9H903
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H903
NP_001138450.1
289
31285
S37
L
V
G
D
N
P
A
S
H
T
Y
V
R
N
K
Chimpanzee
Pan troglodytes
XP_517226
379
40691
S127
L
V
G
D
N
P
A
S
H
T
Y
V
R
N
K
Rhesus Macaque
Macaca mulatta
XP_001091218
502
54417
S250
L
V
G
D
N
P
A
S
H
T
Y
V
R
N
K
Dog
Lupus familis
XP_539316
310
33584
S58
L
V
G
D
N
P
A
S
H
T
Y
V
R
K
K
Cat
Felis silvestris
Mouse
Mus musculus
P18155
350
37844
S81
L
V
G
D
N
P
A
S
H
S
Y
V
L
N
K
Rat
Rattus norvegicus
NP_001100681
338
36408
S86
L
V
G
D
N
P
A
S
H
T
Y
V
R
N
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511115
253
27145
K23
N
E
P
T
S
S
A
K
S
V
P
L
V
T
T
Chicken
Gallus gallus
Q5ZKA5
337
36393
S76
L
V
G
E
N
P
A
S
H
S
Y
V
L
N
K
Frog
Xenopus laevis
NP_001085223
335
36310
S74
L
V
G
D
D
P
A
S
H
S
Y
V
L
N
K
Zebra Danio
Brachydanio rerio
NP_001002181
338
36917
S74
L
V
G
D
N
P
A
S
H
S
Y
V
L
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q04448
309
33532
S52
I
V
G
E
D
P
A
S
E
K
Y
V
A
N
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793717
336
36041
S73
L
V
G
E
D
P
A
S
S
V
Y
V
K
N
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
75.7
56.5
90.3
N.A.
62.5
78.6
N.A.
59.1
62.6
64.1
63.6
N.A.
52
N.A.
N.A.
53.5
Protein Similarity:
100
75.9
57.1
92.2
N.A.
72.8
83.1
N.A.
71.6
74.7
76.7
75.4
N.A.
66
N.A.
N.A.
66.6
P-Site Identity:
100
100
100
93.3
N.A.
86.6
100
N.A.
6.6
80
80
86.6
N.A.
60
N.A.
N.A.
66.6
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
100
N.A.
20
93.3
93.3
93.3
N.A.
80
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
100
0
0
0
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
67
25
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
9
0
25
0
0
0
0
9
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
92
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
75
0
0
0
0
0
0
% H
% Ile:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
9
0
9
0
0
9
9
92
% K
% Leu:
84
0
0
0
0
0
0
0
0
0
0
9
34
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
0
0
67
0
0
0
0
0
0
0
0
84
0
% N
% Pro:
0
0
9
0
0
92
0
0
0
0
9
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
42
0
0
% R
% Ser:
0
0
0
0
9
9
0
92
17
34
0
0
0
0
0
% S
% Thr:
0
0
0
9
0
0
0
0
0
42
0
0
0
9
9
% T
% Val:
0
92
0
0
0
0
0
0
0
17
0
92
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
92
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _