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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD2L
All Species:
39.7
Human Site:
S65
Identified Species:
79.39
UniProt:
Q9H903
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H903
NP_001138450.1
289
31285
S65
I
L
K
P
K
D
V
S
Q
E
E
L
L
D
V
Chimpanzee
Pan troglodytes
XP_517226
379
40691
S155
I
L
K
P
K
D
V
S
Q
E
E
L
L
D
I
Rhesus Macaque
Macaca mulatta
XP_001091218
502
54417
S278
I
L
K
P
K
D
V
S
Q
E
E
L
L
D
I
Dog
Lupus familis
XP_539316
310
33584
S86
I
L
K
P
K
D
V
S
Q
E
E
L
L
D
I
Cat
Felis silvestris
Mouse
Mus musculus
P18155
350
37844
S109
I
V
K
P
A
S
V
S
E
E
E
L
L
N
S
Rat
Rattus norvegicus
NP_001100681
338
36408
S114
I
V
K
P
K
N
V
S
Q
E
E
L
L
D
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511115
253
27145
R51
I
R
R
L
L
C
A
R
H
Y
T
K
R
G
H
Chicken
Gallus gallus
Q5ZKA5
337
36393
T104
I
L
K
P
A
S
I
T
E
E
E
L
L
D
L
Frog
Xenopus laevis
NP_001085223
335
36310
T102
I
L
K
P
T
S
I
T
E
E
E
L
L
D
L
Zebra Danio
Brachydanio rerio
NP_001002181
338
36917
S102
I
L
K
P
S
N
I
S
E
E
E
L
L
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q04448
309
33532
T80
K
R
L
P
A
S
T
T
Q
E
E
L
L
Q
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793717
336
36041
S101
I
T
K
P
A
T
I
S
E
K
E
L
L
A
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
75.7
56.5
90.3
N.A.
62.5
78.6
N.A.
59.1
62.6
64.1
63.6
N.A.
52
N.A.
N.A.
53.5
Protein Similarity:
100
75.9
57.1
92.2
N.A.
72.8
83.1
N.A.
71.6
74.7
76.7
75.4
N.A.
66
N.A.
N.A.
66.6
P-Site Identity:
100
93.3
93.3
93.3
N.A.
60
80
N.A.
6.6
60
60
66.6
N.A.
40
N.A.
N.A.
46.6
P-Site Similarity:
100
100
100
100
N.A.
80
100
N.A.
13.3
86.6
86.6
93.3
N.A.
53.3
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
34
0
9
0
0
0
0
0
0
9
0
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
34
0
0
0
0
0
0
0
67
0
% D
% Glu:
0
0
0
0
0
0
0
0
42
84
92
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% H
% Ile:
92
0
0
0
0
0
34
0
0
0
0
0
0
0
42
% I
% Lys:
9
0
84
0
42
0
0
0
0
9
0
9
0
0
0
% K
% Leu:
0
59
9
9
9
0
0
0
0
0
0
92
92
0
34
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
17
0
0
0
0
0
0
0
9
0
% N
% Pro:
0
0
0
92
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
50
0
0
0
0
9
0
% Q
% Arg:
0
17
9
0
0
0
0
9
0
0
0
0
9
0
0
% R
% Ser:
0
0
0
0
9
34
0
67
0
0
0
0
0
0
9
% S
% Thr:
0
9
0
0
9
9
9
25
0
0
9
0
0
0
0
% T
% Val:
0
17
0
0
0
0
50
0
0
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _