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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFD2L All Species: 39.7
Human Site: T183 Identified Species: 79.39
UniProt: Q9H903 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H903 NP_001138450.1 289 31285 T183 E R P G G D A T V T I A H R Y
Chimpanzee Pan troglodytes XP_517226 379 40691 T273 E R P G G D A T V T I A H R Y
Rhesus Macaque Macaca mulatta XP_001091218 502 54417 T396 E R P G G D A T V T I A H R Y
Dog Lupus familis XP_539316 310 33584 T204 E R P G G D A T V T I A H R Y
Cat Felis silvestris
Mouse Mus musculus P18155 350 37844 T227 E R P G G D A T V T I S H R Y
Rat Rattus norvegicus NP_001100681 338 36408 T232 E R P G G D A T V T I A H R H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511115 253 27145 T155 V T V T H R Y T P R E Q L R M
Chicken Gallus gallus Q5ZKA5 337 36393 T222 E R P G G D A T V T I S H R Y
Frog Xenopus laevis NP_001085223 335 36310 T220 E R P G G D A T V T I S H R Y
Zebra Danio Brachydanio rerio NP_001002181 338 36917 T220 E R P G G D A T V T I S H R Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q04448 309 33532 T198 A T K A M D A T V T I C H R Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793717 336 36041 A219 A S G M G M D A T V T L C H R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 75.7 56.5 90.3 N.A. 62.5 78.6 N.A. 59.1 62.6 64.1 63.6 N.A. 52 N.A. N.A. 53.5
Protein Similarity: 100 75.9 57.1 92.2 N.A. 72.8 83.1 N.A. 71.6 74.7 76.7 75.4 N.A. 66 N.A. N.A. 66.6
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 13.3 93.3 93.3 93.3 N.A. 60 N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 100 100 100 N.A. 60 N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 0 9 0 0 84 9 0 0 0 42 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 9 0 0 % C
% Asp: 0 0 0 0 0 84 9 0 0 0 0 0 0 0 0 % D
% Glu: 75 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 75 84 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 0 84 9 9 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 84 0 0 0 0 % I
% Lys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 9 9 0 0 % L
% Met: 0 0 0 9 9 9 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 75 0 0 0 0 0 9 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % Q
% Arg: 0 75 0 0 0 9 0 0 0 9 0 0 0 92 9 % R
% Ser: 0 9 0 0 0 0 0 0 0 0 0 34 0 0 0 % S
% Thr: 0 17 0 9 0 0 0 92 9 84 9 0 0 0 0 % T
% Val: 9 0 9 0 0 0 0 0 84 9 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 75 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _