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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COG4 All Species: 29.7
Human Site: S110 Identified Species: 54.44
UniProt: Q9H9E3 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H9E3 NP_056201.2 785 89095 S110 N L A E N V S S K V R Q L D L
Chimpanzee Pan troglodytes XP_511080 790 89810 Q109 N P S T L G S Q G R R I D I V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_546836 788 89405 S113 N L A E N V S S K V R Q L D L
Cat Felis silvestris
Mouse Mus musculus Q8R1U1 785 88642 S110 S L A E N V S S K V R Q L D L
Rat Rattus norvegicus NP_001101919 785 88584 S110 N L A E N V S S K V R Q L D L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506619 778 88360 S103 N L A E N V S S K V R Q L D L
Chicken Gallus gallus NP_001012793 771 87570 S96 N L A E N V S S K V R Q L D L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001034912 781 87569 S102 S L A E N V S S K V R Q L D L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95TN4 776 87696 S99 D L A R C R A S E C Q Q R V H
Honey Bee Apis mellifera XP_394599 741 84404 L103 R V N D I L D L Q L C S E G V
Nematode Worm Caenorhab. elegans Q95XZ0 801 91001 G118 V L A D T I S G R V S A L D V
Sea Urchin Strong. purpuratus XP_001204443 753 84933 Q95 N V S S K V R Q L D L A K S L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L838 738 82959 G107 D L A D Q V S G K V R E L D L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.6 N.A. 96.8 N.A. 94.5 94.9 N.A. 90.1 84.5 N.A. 71.8 N.A. 40 45.4 31.2 57.7
Protein Similarity: 100 96.3 N.A. 97.9 N.A. 97.7 97.8 N.A. 95.4 91.4 N.A. 85.7 N.A. 62.7 66.6 54.8 73.5
P-Site Identity: 100 20 N.A. 100 N.A. 93.3 100 N.A. 100 100 N.A. 93.3 N.A. 26.6 0 40 20
P-Site Similarity: 100 33.3 N.A. 100 N.A. 100 100 N.A. 100 100 N.A. 100 N.A. 53.3 40 66.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. 33.1 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 56.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 66.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 86.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 77 0 0 0 8 0 0 0 0 16 0 0 0 % A
% Cys: 0 0 0 0 8 0 0 0 0 8 8 0 0 0 0 % C
% Asp: 16 0 0 24 0 0 8 0 0 8 0 0 8 70 0 % D
% Glu: 0 0 0 54 0 0 0 0 8 0 0 8 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 0 16 8 0 0 0 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 0 0 0 8 8 0 0 0 0 0 8 0 8 0 % I
% Lys: 0 0 0 0 8 0 0 0 62 0 0 0 8 0 0 % K
% Leu: 0 77 0 0 8 8 0 8 8 8 8 0 70 0 70 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 54 0 8 0 54 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 8 0 0 16 8 0 8 62 0 0 0 % Q
% Arg: 8 0 0 8 0 8 8 0 8 8 70 0 8 0 0 % R
% Ser: 16 0 16 8 0 0 77 62 0 0 8 8 0 8 0 % S
% Thr: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 0 % T
% Val: 8 16 0 0 0 70 0 0 0 70 0 0 0 8 24 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _