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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COG4 All Species: 38.79
Human Site: T695 Identified Species: 71.11
UniProt: Q9H9E3 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H9E3 NP_056201.2 785 89095 T695 E K V V L K S T F N R L G G L
Chimpanzee Pan troglodytes XP_511080 790 89810 T700 E K V V L K S T F N R L G G L
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_546836 788 89405 T698 E R V V L K S T F N R L G G L
Cat Felis silvestris
Mouse Mus musculus Q8R1U1 785 88642 T695 E K V V L K S T F N R L G G L
Rat Rattus norvegicus NP_001101919 785 88584 T695 E K V V L K S T F N R L G G L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506619 778 88360 T688 E K V V L K S T F S R L G G L
Chicken Gallus gallus NP_001012793 771 87570 S681 E K V L L K S S F N R L G G L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001034912 781 87569 T691 E K T V F K C T F S R L G G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95TN4 776 87696 S684 E R A I K K I S F N R L G G L
Honey Bee Apis mellifera XP_394599 741 84404 T653 E K V V L K S T F N R A G G L
Nematode Worm Caenorhab. elegans Q95XZ0 801 91001 Q708 E Q S L A K C Q F N R Y G A L
Sea Urchin Strong. purpuratus XP_001204443 753 84933 V663 E K A V L K S V F N R L G G L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L838 738 82959 R648 E V I M M Q K R F S Q L G G L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.6 N.A. 96.8 N.A. 94.5 94.9 N.A. 90.1 84.5 N.A. 71.8 N.A. 40 45.4 31.2 57.7
Protein Similarity: 100 96.3 N.A. 97.9 N.A. 97.7 97.8 N.A. 95.4 91.4 N.A. 85.7 N.A. 62.7 66.6 54.8 73.5
P-Site Identity: 100 100 N.A. 93.3 N.A. 100 100 N.A. 93.3 86.6 N.A. 73.3 N.A. 60 93.3 46.6 86.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 N.A. 80 N.A. 80 93.3 60 86.6
Percent
Protein Identity: N.A. N.A. N.A. 33.1 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 56.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 40 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 80 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 16 0 8 0 0 0 0 0 0 8 0 8 0 % A
% Cys: 0 0 0 0 0 0 16 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 8 0 0 0 100 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 100 93 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 8 0 0 8 0 0 0 0 0 0 0 0 % I
% Lys: 0 70 0 0 8 93 8 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 16 70 0 0 0 0 0 0 85 0 0 100 % L
% Met: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 77 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 8 0 0 0 8 0 8 0 0 8 0 0 0 0 % Q
% Arg: 0 16 0 0 0 0 0 8 0 0 93 0 0 0 0 % R
% Ser: 0 0 8 0 0 0 70 16 0 24 0 0 0 0 0 % S
% Thr: 0 0 8 0 0 0 0 62 0 0 0 0 0 0 0 % T
% Val: 0 8 62 70 0 0 0 8 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _