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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C3
All Species:
39.7
Human Site:
S254
Identified Species:
72.78
UniProt:
Q9H9G7
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H9G7
NP_079128.2
860
97360
S254
Q
P
R
P
L
T
D
S
H
R
V
K
F
T
K
Chimpanzee
Pan troglodytes
XP_524664
845
95948
S239
Q
P
R
P
L
T
D
S
H
R
V
K
F
T
K
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
S445
Q
Q
K
P
L
T
D
S
Q
R
V
K
F
T
K
Dog
Lupus familis
XP_532562
881
100044
S270
Q
P
R
P
L
T
D
S
H
R
V
K
F
T
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJF9
860
97222
S254
Q
P
R
P
L
T
D
S
H
R
V
K
F
T
K
Rat
Rattus norvegicus
Q9QZ81
860
97300
S254
Q
Q
K
P
L
T
D
S
Q
R
V
K
F
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510243
1052
118200
S446
Q
P
R
P
L
T
D
S
H
R
V
K
F
T
K
Chicken
Gallus gallus
Q5ZLG4
860
97253
S254
Q
P
R
P
L
T
D
S
H
R
V
K
F
T
K
Frog
Xenopus laevis
Q4KLV6
884
99519
S266
Q
T
K
P
L
T
D
S
Q
R
V
K
F
T
K
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
S254
Q
P
R
P
L
T
D
S
H
R
V
K
F
T
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
N622
A
K
I
N
N
T
T
N
L
D
Y
S
R
R
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
S391
L
S
R
D
T
Q
L
S
S
F
E
T
R
I
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
A409
S
S
R
P
L
S
D
A
D
R
V
K
I
K
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.2
62.2
97.1
N.A.
98.7
80.2
N.A.
81.4
99
80.1
95.1
N.A.
22.9
N.A.
32.3
N.A.
Protein Similarity:
100
98.2
71.9
97.3
N.A.
99
89.7
N.A.
81.5
99.1
88.3
97.7
N.A.
36.4
N.A.
50
N.A.
P-Site Identity:
100
100
80
100
N.A.
100
80
N.A.
100
100
80
100
N.A.
6.6
N.A.
13.3
N.A.
P-Site Similarity:
100
100
86.6
100
N.A.
100
86.6
N.A.
100
100
86.6
100
N.A.
13.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
85
0
8
8
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
77
0
16
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
54
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
0
0
8
8
0
% I
% Lys:
0
8
24
0
0
0
0
0
0
0
0
85
0
8
85
% K
% Leu:
8
0
0
0
85
0
8
0
8
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
8
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
54
0
85
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
77
16
0
0
0
8
0
0
24
0
0
0
0
0
0
% Q
% Arg:
0
0
70
0
0
0
0
0
0
85
0
0
16
8
0
% R
% Ser:
8
16
0
0
0
8
0
85
8
0
0
8
0
0
0
% S
% Thr:
0
8
0
0
8
85
8
0
0
0
0
8
0
77
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
85
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _