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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C3
All Species:
29.7
Human Site:
T110
Identified Species:
54.44
UniProt:
Q9H9G7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H9G7
NP_079128.2
860
97360
T110
T
G
V
D
L
D
V
T
L
P
G
E
G
G
K
Chimpanzee
Pan troglodytes
XP_524664
845
95948
T95
T
G
V
D
L
D
V
T
L
P
G
E
G
G
K
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
G301
T
A
M
P
L
P
I
G
R
D
K
V
E
L
E
Dog
Lupus familis
XP_532562
881
100044
T126
T
G
V
D
L
D
V
T
L
P
G
E
G
G
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJF9
860
97222
T110
T
G
V
D
L
D
V
T
L
P
G
E
G
G
K
Rat
Rattus norvegicus
Q9QZ81
860
97300
G110
T
A
M
P
L
P
I
G
R
D
K
V
E
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510243
1052
118200
T302
T
G
V
D
L
D
V
T
L
P
G
E
G
G
K
Chicken
Gallus gallus
Q5ZLG4
860
97253
T110
T
G
V
D
L
D
V
T
L
P
G
E
G
G
K
Frog
Xenopus laevis
Q4KLV6
884
99519
G122
T
A
H
P
L
P
I
G
R
D
R
V
D
L
E
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
T110
A
G
V
D
L
D
V
T
L
P
G
E
G
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
S483
V
D
K
L
P
L
N
S
Q
N
P
E
V
T
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
S188
V
R
L
D
C
E
A
S
L
P
K
D
N
R
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
R268
P
F
N
S
K
E
F
R
I
N
L
L
D
E
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.2
62.2
97.1
N.A.
98.7
80.2
N.A.
81.4
99
80.1
95.1
N.A.
22.9
N.A.
32.3
N.A.
Protein Similarity:
100
98.2
71.9
97.3
N.A.
99
89.7
N.A.
81.5
99.1
88.3
97.7
N.A.
36.4
N.A.
50
N.A.
P-Site Identity:
100
100
13.3
100
N.A.
100
13.3
N.A.
100
100
13.3
93.3
N.A.
6.6
N.A.
20
N.A.
P-Site Similarity:
100
100
33.3
100
N.A.
100
33.3
N.A.
100
100
26.6
93.3
N.A.
13.3
N.A.
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
24
0
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
62
0
54
0
0
0
24
0
8
16
0
8
% D
% Glu:
0
0
0
0
0
16
0
0
0
0
0
62
16
8
31
% E
% Phe:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
54
0
0
0
0
0
24
0
0
54
0
54
54
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
24
0
8
0
0
0
0
0
0
% I
% Lys:
0
0
8
0
8
0
0
0
0
0
24
0
0
0
54
% K
% Leu:
0
0
8
8
77
8
0
0
62
0
8
8
0
24
0
% L
% Met:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
8
0
0
16
0
0
8
0
0
% N
% Pro:
8
0
0
24
8
24
0
0
0
62
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
8
24
0
8
0
0
8
0
% R
% Ser:
0
0
0
8
0
0
0
16
0
0
0
0
0
0
0
% S
% Thr:
70
0
0
0
0
0
0
54
0
0
0
0
0
8
0
% T
% Val:
16
0
54
0
0
0
54
0
0
0
0
24
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _