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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2C3 All Species: 22.42
Human Site: T141 Identified Species: 41.11
UniProt: Q9H9G7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H9G7 NP_079128.2 860 97360 T141 H L L H E V L T G R T L P E P
Chimpanzee Pan troglodytes XP_524664 845 95948 T126 H L L H E V L T G R T L P E P
Rhesus Macaque Macaca mulatta XP_001100725 1053 117937 L332 K W V S C V S L Q A L H D A L
Dog Lupus familis XP_532562 881 100044 T157 H L L H E V L T G R T L P E P
Cat Felis silvestris
Mouse Mus musculus Q8CJF9 860 97222 A141 H L L H E A L A G G T L P E P
Rat Rattus norvegicus Q9QZ81 860 97300 L141 K W V S C V S L Q A L H D A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510243 1052 118200 T333 H L L H E V L T G R T L P E P
Chicken Gallus gallus Q5ZLG4 860 97253 T141 H L L H E V L T G R T L P E P
Frog Xenopus laevis Q4KLV6 884 99519 L153 Q W V S V V S L Q L L L E A L
Zebra Danio Brachydanio rerio A3KPK0 860 97313 T141 H M L H E V L T G R S T P D P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUQ5 1214 136831 L514 T G D S T I D L K S L T T Y M
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34681 1040 115397 N219 E M Q R T R T N N L D E R V L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04379 1048 116172 L299 K L V A R A D L H H L G M F L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.2 62.2 97.1 N.A. 98.7 80.2 N.A. 81.4 99 80.1 95.1 N.A. 22.9 N.A. 32.3 N.A.
Protein Similarity: 100 98.2 71.9 97.3 N.A. 99 89.7 N.A. 81.5 99.1 88.3 97.7 N.A. 36.4 N.A. 50 N.A.
P-Site Identity: 100 100 6.6 100 N.A. 80 6.6 N.A. 100 100 13.3 73.3 N.A. 0 N.A. 0 N.A.
P-Site Similarity: 100 100 13.3 100 N.A. 80 13.3 N.A. 100 100 20 93.3 N.A. 6.6 N.A. 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 36.8 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 51.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 16 0 8 0 16 0 0 0 24 0 % A
% Cys: 0 0 0 0 16 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 0 16 0 0 0 8 0 16 8 0 % D
% Glu: 8 0 0 0 54 0 0 0 0 0 0 8 8 47 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 8 0 0 0 0 0 0 54 8 0 8 0 0 0 % G
% His: 54 0 0 54 0 0 0 0 8 8 0 16 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % I
% Lys: 24 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % K
% Leu: 0 54 54 0 0 0 54 39 0 16 39 54 0 0 39 % L
% Met: 0 16 0 0 0 0 0 0 0 0 0 0 8 0 8 % M
% Asn: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 54 0 54 % P
% Gln: 8 0 8 0 0 0 0 0 24 0 0 0 0 0 0 % Q
% Arg: 0 0 0 8 8 8 0 0 0 47 0 0 8 0 0 % R
% Ser: 0 0 0 31 0 0 24 0 0 8 8 0 0 0 0 % S
% Thr: 8 0 0 0 16 0 8 47 0 0 47 16 8 0 0 % T
% Val: 0 0 31 0 8 70 0 0 0 0 0 0 0 8 0 % V
% Trp: 0 24 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _