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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C3
All Species:
27.27
Human Site:
Y682
Identified Species:
50
UniProt:
Q9H9G7
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H9G7
NP_079128.2
860
97360
Y682
G
Q
F
R
Q
V
L
Y
Y
E
L
L
A
I
R
Chimpanzee
Pan troglodytes
XP_524664
845
95948
Y667
G
Q
F
R
Q
V
L
Y
Y
E
L
L
A
I
R
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
H875
G
Q
F
Q
Q
V
L
H
H
E
L
L
A
I
R
Dog
Lupus familis
XP_532562
881
100044
Y703
G
Q
F
R
Q
V
L
Y
Y
E
L
L
A
I
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJF9
860
97222
Y682
G
Q
F
R
Q
V
L
Y
Y
E
L
L
A
I
R
Rat
Rattus norvegicus
Q9QZ81
860
97300
H682
G
Q
F
Q
Q
V
L
H
H
E
L
L
A
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510243
1052
118200
Y874
G
Q
F
R
Q
V
L
Y
Y
E
L
L
A
I
R
Chicken
Gallus gallus
Q5ZLG4
860
97253
Y682
G
Q
F
R
Q
V
L
Y
Y
E
L
L
A
I
R
Frog
Xenopus laevis
Q4KLV6
884
99519
W706
G
Q
M
K
Q
V
A
W
P
E
L
M
A
I
R
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
Y682
G
Q
F
R
Q
V
L
Y
Y
E
L
L
A
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
V1039
I
I
Y
Y
R
D
G
V
S
D
G
Q
F
P
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
R829
G
Q
F
S
E
V
L
R
E
E
I
Q
S
I
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
E860
F
Y
Q
V
L
L
Y
E
L
D
A
I
R
K
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.2
62.2
97.1
N.A.
98.7
80.2
N.A.
81.4
99
80.1
95.1
N.A.
22.9
N.A.
32.3
N.A.
Protein Similarity:
100
98.2
71.9
97.3
N.A.
99
89.7
N.A.
81.5
99.1
88.3
97.7
N.A.
36.4
N.A.
50
N.A.
P-Site Identity:
100
100
80
100
N.A.
100
80
N.A.
100
100
60
100
N.A.
0
N.A.
53.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
80
100
N.A.
26.6
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
0
8
0
77
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
0
0
0
16
0
0
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
8
8
85
0
0
0
0
0
% E
% Phe:
8
0
77
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
85
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
16
16
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
0
0
0
0
0
0
8
8
0
85
0
% I
% Lys:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
8
% K
% Leu:
0
0
0
0
8
8
77
0
8
0
77
70
0
0
0
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% P
% Gln:
0
85
8
16
77
0
0
0
0
0
0
16
0
0
0
% Q
% Arg:
0
0
0
54
8
0
0
8
0
0
0
0
8
0
85
% R
% Ser:
0
0
0
8
0
0
0
0
8
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
8
0
85
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
8
8
8
0
0
8
54
54
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _