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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SEC61A2 All Species: 59.7
Human Site: S408 Identified Species: 93.81
UniProt: Q9H9S3 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H9S3 NP_001136099.1 476 52248 S408 M R G H R D T S M V H E L N R
Chimpanzee Pan troglodytes XP_507657 551 59257 S483 M R G H R D T S M V H E L N R
Rhesus Macaque Macaca mulatta XP_001085071 1486 164008 S1418 M R G H R D T S M V H E L N R
Dog Lupus familis XP_535191 551 60482 S483 M R G H R D T S M V H E L N R
Cat Felis silvestris
Mouse Mus musculus Q9JLR1 476 52229 S408 M R G H R D T S M V H E L N R
Rat Rattus norvegicus P61621 476 52246 S408 M R G H R E T S M V H E L N R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515762 609 66529 S541 M R G H R D T S M V H E L N R
Chicken Gallus gallus XP_424024 535 57647 S467 M R G H R D T S M V H E L N R
Frog Xenopus laevis NP_001080244 476 52132 S408 M R G H R E T S M V H E L N R
Zebra Danio Brachydanio rerio Q90ZM2 476 52279 S408 M R G H R E T S M V H E L N R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609034 476 52166 S408 M R G H R E N S M I H E L N R
Honey Bee Apis mellifera XP_001120255 476 52370 S408 M R G H R D N S M I H E L N R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_802085 475 52232 S407 M R G H R E K S M I H E L N R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32915 480 52918 S409 I N G K R E T S I Y R E L K K
Red Bread Mold Neurospora crassa Q870W0 476 52293 S408 M A G H R E Q S M Y K E L K R
Conservation
Percent
Protein Identity: 100 86.3 32 86.3 N.A. 100 93.4 N.A. 77.8 88.5 93.4 94.5 N.A. 91.1 89.5 N.A. 89.5
Protein Similarity: 100 86.3 32 86.3 N.A. 100 97 N.A. 78.1 88.9 97.4 97.6 N.A. 96.4 96 N.A. 94.9
P-Site Identity: 100 100 100 100 N.A. 100 93.3 N.A. 100 100 93.3 93.3 N.A. 80 86.6 N.A. 80
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 93.3 93.3 N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 54.7 64.2
Protein Similarity: N.A. N.A. N.A. N.A. 72.2 79.6
P-Site Identity: N.A. N.A. N.A. N.A. 40 60
P-Site Similarity: N.A. N.A. N.A. N.A. 66.6 66.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 54 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 47 0 0 0 0 0 100 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 94 0 0 0 0 0 0 87 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 0 0 7 20 0 0 0 0 0 % I
% Lys: 0 0 0 7 0 0 7 0 0 0 7 0 0 14 7 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 % L
% Met: 94 0 0 0 0 0 0 0 94 0 0 0 0 0 0 % M
% Asn: 0 7 0 0 0 0 14 0 0 0 0 0 0 87 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Q
% Arg: 0 87 0 0 100 0 0 0 0 0 7 0 0 0 94 % R
% Ser: 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 74 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 67 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 14 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _