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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR1B All Species: 33.03
Human Site: Y703 Identified Species: 51.9
UniProt: Q9H9Y6 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H9Y6 NP_001131076.1 1135 128229 Y703 M G F P L L T Y Q D R S D N K
Chimpanzee Pan troglodytes XP_515692 1135 128294 Y703 M G F P I L T Y Q D R S D N K
Rhesus Macaque Macaca mulatta XP_001088474 1135 128257 Y703 M G F P L L T Y Q D R S D N K
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P70700 1135 127957 Y703 M G F P L L T Y Q N R S D N K
Rat Rattus norvegicus O54888 1135 127691 Y703 M G F P L L T Y Q D R S D N K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515678 1146 129549 Y714 M G F P L N T Y R E R S D N K
Chicken Gallus gallus XP_415007 1041 117633 Q624 L Y L L H T P Q S P L V R P R
Frog Xenopus laevis NP_001080005 1134 128197 Y702 M G F P L M T Y Q D R S D N K
Zebra Danio Brachydanio rerio NP_956812 1132 127666 Y701 M G F P L H S Y Q Y R S D N K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P20028 1129 128426 W701 M G T P C L N W P K Q A A N K
Honey Bee Apis mellifera XP_001120416 1121 127333 W696 M G T P C H T W Q L Q S E T K
Nematode Worm Caenorhab. elegans Q10578 1193 134886 F746 M G V Y T T N F H V R M D T L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P38420 1188 135001 Y748 M G I Y V T N Y Q F R M D T L
Baker's Yeast Sacchar. cerevisiae P22138 1203 135723 L733 M G T P G V A L C H R S D N K
Red Bread Mold Neurospora crassa O74633 1234 138583 L736 M G T P A T A L A H R T D N K
Conservation
Percent
Protein Identity: 100 99.5 98.6 N.A. N.A. 89.6 85.2 N.A. 83.5 68.1 77 75.7 N.A. 45.2 47.1 28.3 N.A.
Protein Similarity: 100 99.8 99.5 N.A. N.A. 95.4 90.3 N.A. 92.8 79.5 88.9 89.2 N.A. 64.9 66 44.9 N.A.
P-Site Identity: 100 93.3 100 N.A. N.A. 93.3 100 N.A. 80 0 93.3 80 N.A. 40 46.6 26.6 N.A.
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. 93.3 13.3 100 86.6 N.A. 60 66.6 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 25.8 42.4 44
Protein Similarity: N.A. N.A. N.A. 42.8 61.9 60.7
P-Site Identity: N.A. N.A. N.A. 40 53.3 46.6
P-Site Similarity: N.A. N.A. N.A. 46.6 60 53.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 7 0 14 0 7 0 0 7 7 0 0 % A
% Cys: 0 0 0 0 14 0 0 0 7 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 34 0 0 80 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 7 0 0 7 0 0 % E
% Phe: 0 0 54 0 0 0 0 7 0 7 0 0 0 0 0 % F
% Gly: 0 94 0 0 7 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 7 14 0 0 7 14 0 0 0 0 0 % H
% Ile: 0 0 7 0 7 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 80 % K
% Leu: 7 0 7 7 47 40 0 14 0 7 7 0 0 0 14 % L
% Met: 94 0 0 0 0 7 0 0 0 0 0 14 0 0 0 % M
% Asn: 0 0 0 0 0 7 20 0 0 7 0 0 0 74 0 % N
% Pro: 0 0 0 80 0 0 7 0 7 7 0 0 0 7 0 % P
% Gln: 0 0 0 0 0 0 0 7 60 0 14 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 7 0 80 0 7 0 7 % R
% Ser: 0 0 0 0 0 0 7 0 7 0 0 67 0 0 0 % S
% Thr: 0 0 27 0 7 27 54 0 0 0 0 7 0 20 0 % T
% Val: 0 0 7 0 7 7 0 0 0 7 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 14 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 14 0 0 0 60 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _