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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UPF2 All Species: 30
Human Site: S908 Identified Species: 55
UniProt: Q9HAU5 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HAU5 NP_056357.1 1272 147810 S908 V N P D G S P S S L D P P E H
Chimpanzee Pan troglodytes XP_507656 1448 165981 S1084 V N P D G S P S S L D P P E H
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_857902 1271 147822 S907 V N S D G S P S S L D P P E H
Cat Felis silvestris
Mouse Mus musculus NP_001074601 1269 147534 S906 V N P D G S P S S L D P P E H
Rat Rattus norvegicus NP_001101891 1268 147324 S906 V N P D G S P S S L D P P E H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_417288 1272 147721 S908 V N P D G S P S P L D P P E H
Frog Xenopus laevis NP_001089661 1264 146847 S900 V N S D G S P S P L D P P E H
Zebra Danio Brachydanio rerio XP_697460 594 68181 L276 L H C L K M L L S D F S H H H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572434 1241 140038 S852 S N D Q N V V S P L D P P D S
Honey Bee Apis mellifera XP_396597 1132 130343 S803 G Q Y F S G G S S K K K L D Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002315268 1194 135972 D810 G H D T P E Q D V L D P P E D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_181459 1181 133943 E803 G H D T S E Q E V L D P P E D
Baker's Yeast Sacchar. cerevisiae P38798 1089 126729 T771 E Q P L P K E T E F R V S S T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.7 N.A. 97.7 N.A. 96.9 97 N.A. N.A. 93.2 86.4 40 N.A. 36.3 45.5 N.A. N.A.
Protein Similarity: 100 87.7 N.A. 99 N.A. 98.7 98.6 N.A. N.A. 97.4 93.2 44.2 N.A. 56 62.8 N.A. N.A.
P-Site Identity: 100 100 N.A. 93.3 N.A. 100 100 N.A. N.A. 93.3 86.6 13.3 N.A. 40 13.3 N.A. N.A.
P-Site Similarity: 100 100 N.A. 93.3 N.A. 100 100 N.A. N.A. 93.3 86.6 26.6 N.A. 46.6 26.6 N.A. N.A.
Percent
Protein Identity: 37.1 N.A. N.A. 34.4 21.3 N.A.
Protein Similarity: 54.2 N.A. N.A. 53 40.9 N.A.
P-Site Identity: 33.3 N.A. N.A. 33.3 6.6 N.A.
P-Site Similarity: 40 N.A. N.A. 40 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 24 54 0 0 0 8 0 8 77 0 0 16 16 % D
% Glu: 8 0 0 0 0 16 8 8 8 0 0 0 0 70 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 8 8 0 0 0 0 % F
% Gly: 24 0 0 0 54 8 8 0 0 0 0 0 0 0 0 % G
% His: 0 24 0 0 0 0 0 0 0 0 0 0 8 8 62 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 8 8 0 0 0 8 8 8 0 0 0 % K
% Leu: 8 0 0 16 0 0 8 8 0 77 0 0 8 0 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 62 0 0 8 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 47 0 16 0 54 0 24 0 0 77 77 0 0 % P
% Gln: 0 16 0 8 0 0 16 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % R
% Ser: 8 0 16 0 16 54 0 70 54 0 0 8 8 8 8 % S
% Thr: 0 0 0 16 0 0 0 8 0 0 0 0 0 0 8 % T
% Val: 54 0 0 0 0 8 8 0 16 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _