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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLSPN All Species: 15.15
Human Site: S721 Identified Species: 37.04
UniProt: Q9HAW4 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HAW4 NP_071394.2 1339 151094 S721 S V P K S L S S D S T L L L F
Chimpanzee Pan troglodytes XP_001167189 1273 143970 S656 S V P K S L S S D S T L L L F
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539598 1574 177075 S956 S V P K P L S S D S T L L L F
Cat Felis silvestris
Mouse Mus musculus Q80YR7 1315 146671 S699 C V P K P L S S D S T L L L F
Rat Rattus norvegicus NP_001100157 1223 136693 E632 S E E D G E E E E E E E E E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510157 1511 167716 S886 P K P A T S E S T L L L F K D
Chicken Gallus gallus XP_425782 1387 154373 S764 P K P P S T E S T L M L F K D
Frog Xenopus laevis Q9DF50 1285 145963 P668 N V P E I V I P L P R P V T T
Zebra Danio Brachydanio rerio XP_002665647 920 101092 R333 R T G D G V R R I G A A G H E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001121723 780 90984 G193 D A K L E K P G A K L K R L K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.5 N.A. 72.4 N.A. 75.5 71.6 N.A. 55.9 51.7 46.2 33.9 N.A. N.A. 20.6 N.A. N.A.
Protein Similarity: 100 94.8 N.A. 77.4 N.A. 84.1 79 N.A. 66.7 66.9 63.4 46.1 N.A. N.A. 36.1 N.A. N.A.
P-Site Identity: 100 100 N.A. 93.3 N.A. 86.6 6.6 N.A. 20 26.6 13.3 0 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 100 100 N.A. 93.3 N.A. 86.6 13.3 N.A. 26.6 26.6 40 6.6 N.A. N.A. 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 10 0 0 0 0 10 0 10 10 0 0 0 % A
% Cys: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 20 0 0 0 0 40 0 0 0 0 0 20 % D
% Glu: 0 10 10 10 10 10 30 10 10 10 10 10 10 10 20 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 20 0 40 % F
% Gly: 0 0 10 0 20 0 0 10 0 10 0 0 10 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 0 0 0 0 10 0 10 0 10 0 0 0 0 0 0 % I
% Lys: 0 20 10 40 0 10 0 0 0 10 0 10 0 20 10 % K
% Leu: 0 0 0 10 0 40 0 0 10 20 20 60 40 50 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % M
% Asn: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 20 0 70 10 20 0 10 10 0 10 0 10 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 10 0 0 0 0 0 10 10 0 0 10 0 10 0 0 % R
% Ser: 40 0 0 0 30 10 40 60 0 40 0 0 0 0 0 % S
% Thr: 0 10 0 0 10 10 0 0 20 0 40 0 0 10 10 % T
% Val: 0 50 0 0 0 20 0 0 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _