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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TRPV4
All Species:
22.12
Human Site:
S422
Identified Species:
60.83
UniProt:
Q9HBA0
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HBA0
NP_067638.3
871
98281
S422
Y
S
S
L
Y
D
L
S
S
L
D
T
C
G
E
Chimpanzee
Pan troglodytes
XP_001170188
764
85825
V338
W
C
Y
G
P
V
R
V
S
L
Y
D
L
A
S
Rhesus Macaque
Macaca mulatta
XP_001098148
722
82073
R297
Y
N
S
K
I
E
N
R
H
E
M
L
A
V
E
Dog
Lupus familis
XP_546641
742
82829
R317
I
F
R
H
I
L
Q
R
E
F
S
G
P
C
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9EPK8
871
98008
S422
Y
S
S
L
Y
D
L
S
S
L
D
T
C
G
E
Rat
Rattus norvegicus
Q9ERZ8
871
97991
S422
Y
S
S
L
Y
D
L
S
S
L
D
T
C
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508791
846
96380
S392
H
S
S
L
Y
D
L
S
C
I
D
T
C
E
K
Chicken
Gallus gallus
NP_990023
852
96180
S408
Y
S
S
L
Y
D
L
S
S
L
D
T
C
G
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001036195
841
95517
S414
Y
S
N
L
Y
D
L
S
S
L
D
T
C
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.2
80.8
40
N.A.
95.2
94.8
N.A.
45.8
84
N.A.
69.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
55.5
81.7
54.8
N.A.
97.5
97.3
N.A.
63.3
90.8
N.A.
80
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
13.3
20
0
N.A.
100
100
N.A.
66.6
100
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
33.3
6.6
N.A.
100
100
N.A.
86.6
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
12
12
0
% A
% Cys:
0
12
0
0
0
0
0
0
12
0
0
0
67
12
0
% C
% Asp:
0
0
0
0
0
67
0
0
0
0
67
12
0
0
0
% D
% Glu:
0
0
0
0
0
12
0
0
12
12
0
0
0
12
67
% E
% Phe:
0
12
0
0
0
0
0
0
0
12
0
0
0
0
0
% F
% Gly:
0
0
0
12
0
0
0
0
0
0
0
12
0
56
0
% G
% His:
12
0
0
12
0
0
0
0
12
0
0
0
0
0
0
% H
% Ile:
12
0
0
0
23
0
0
0
0
12
0
0
0
0
0
% I
% Lys:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
12
% K
% Leu:
0
0
0
67
0
12
67
0
0
67
0
12
12
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% M
% Asn:
0
12
12
0
0
0
12
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
12
0
0
0
0
0
0
0
12
0
0
% P
% Gln:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
12
% Q
% Arg:
0
0
12
0
0
0
12
23
0
0
0
0
0
0
0
% R
% Ser:
0
67
67
0
0
0
0
67
67
0
12
0
0
0
12
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
67
0
0
0
% T
% Val:
0
0
0
0
0
12
0
12
0
0
0
0
0
12
0
% V
% Trp:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
67
0
12
0
67
0
0
0
0
0
12
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _