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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMBIM4
All Species:
20.91
Human Site:
S145
Identified Species:
35.38
UniProt:
Q9HC24
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HC24
NP_057140.2
238
26959
S145
L
T
V
Y
T
L
Q
S
K
K
D
F
S
K
F
Chimpanzee
Pan troglodytes
XP_001162738
238
26906
S145
L
T
V
Y
T
L
Q
S
K
K
D
F
S
K
F
Rhesus Macaque
Macaca mulatta
XP_001117063
225
25339
A145
K
F
G
A
G
L
F
A
L
L
W
I
L
C
L
Dog
Lupus familis
XP_531662
238
26812
S145
L
T
V
Y
T
L
Q
S
K
R
D
F
S
K
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9DA39
238
26628
S145
L
T
A
Y
T
L
Q
S
K
R
D
F
T
K
F
Rat
Rattus norvegicus
O88407
316
35017
T216
V
T
I
F
S
F
Q
T
K
F
D
F
T
S
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510640
238
26687
S145
L
T
A
Y
T
L
Q
S
K
R
D
F
S
K
F
Chicken
Gallus gallus
XP_001235093
237
26659
R146
A
Y
T
L
Q
S
K
R
D
F
S
K
F
G
A
Frog
Xenopus laevis
NP_001089282
235
26315
D145
F
T
F
Q
S
K
R
D
F
S
K
F
G
A
G
Zebra Danio
Brachydanio rerio
NP_998303
236
26689
R145
A
Y
T
F
Q
S
K
R
D
F
S
K
L
G
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11080
276
30391
N184
L
F
A
Y
T
L
Q
N
K
R
D
F
S
V
G
Sea Urchin
Strong. purpuratus
XP_001177352
238
26595
R145
L
V
F
T
V
Q
S
R
K
D
F
S
T
W
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A20
256
28150
A160
L
T
A
Y
T
F
W
A
A
K
K
G
K
D
F
Baker's Yeast
Sacchar. cerevisiae
P48558
297
33627
L161
T
L
S
E
A
Y
C
L
S
L
V
T
L
A
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
91.5
89
N.A.
84.4
23.1
N.A.
81.9
77.3
70.5
64.7
N.A.
N.A.
N.A.
30.7
50.4
Protein Similarity:
100
99.5
92.8
95.3
N.A.
93.2
38.2
N.A.
89.9
85.7
86.1
84
N.A.
N.A.
N.A.
51.8
73.1
P-Site Identity:
100
100
6.6
93.3
N.A.
80
33.3
N.A.
86.6
0
13.3
0
N.A.
N.A.
N.A.
60
13.3
P-Site Similarity:
100
100
13.3
100
N.A.
93.3
73.3
N.A.
93.3
6.6
26.6
13.3
N.A.
N.A.
N.A.
73.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.1
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.5
44.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
29
8
8
0
0
15
8
0
0
0
0
15
15
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
8
% C
% Asp:
0
0
0
0
0
0
0
8
15
8
50
0
0
8
0
% D
% Glu:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
8
15
15
15
0
15
8
0
8
22
8
58
8
0
43
% F
% Gly:
0
0
8
0
8
0
0
0
0
0
0
8
8
15
22
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
8
0
0
0
0
8
15
0
58
22
15
15
8
36
0
% K
% Leu:
58
8
0
8
0
50
0
8
8
15
0
0
22
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
15
8
50
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
22
0
29
0
0
0
0
0
% R
% Ser:
0
0
8
0
15
15
8
36
8
8
15
8
36
8
0
% S
% Thr:
8
58
15
8
50
0
0
8
0
0
0
8
22
0
0
% T
% Val:
8
8
22
0
8
0
0
0
0
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
8
0
0
8
0
% W
% Tyr:
0
15
0
50
0
8
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _