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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMBIM4
All Species:
24.24
Human Site:
S80
Identified Species:
41.03
UniProt:
Q9HC24
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HC24
NP_057140.2
238
26959
S80
I
L
L
F
A
L
G
S
L
G
L
I
F
A
L
Chimpanzee
Pan troglodytes
XP_001162738
238
26906
S80
I
L
L
F
A
L
G
S
L
G
L
I
F
A
L
Rhesus Macaque
Macaca mulatta
XP_001117063
225
25339
K80
A
L
T
L
N
R
H
K
Y
P
L
N
L
Y
L
Dog
Lupus familis
XP_531662
238
26812
S80
I
L
V
F
A
L
G
S
L
G
L
I
F
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9DA39
238
26628
S80
I
V
V
F
A
L
G
S
L
G
L
I
F
A
L
Rat
Rattus norvegicus
O88407
316
35017
T151
S
Y
A
V
F
F
A
T
Y
L
T
L
A
C
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510640
238
26687
S80
I
L
V
S
V
L
G
S
F
G
L
I
I
A
L
Chicken
Gallus gallus
XP_001235093
237
26659
A81
I
S
V
F
G
C
L
A
I
S
F
A
L
A
L
Frog
Xenopus laevis
NP_001089282
235
26315
T80
S
V
I
G
S
L
G
T
V
I
A
L
T
I
Y
Zebra Danio
Brachydanio rerio
NP_998303
236
26689
I80
I
S
A
I
G
S
L
I
L
L
L
A
L
A
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11080
276
30391
S119
V
F
P
N
L
L
G
S
I
A
L
I
I
A
L
Sea Urchin
Strong. purpuratus
XP_001177352
238
26595
F80
M
I
A
F
V
L
S
F
I
F
L
V
A
L
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A20
256
28150
P95
L
L
F
L
C
I
V
P
F
I
L
I
W
P
L
Baker's Yeast
Sacchar. cerevisiae
P48558
297
33627
S96
F
Y
I
C
M
V
V
S
L
V
S
C
I
W
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
91.5
89
N.A.
84.4
23.1
N.A.
81.9
77.3
70.5
64.7
N.A.
N.A.
N.A.
30.7
50.4
Protein Similarity:
100
99.5
92.8
95.3
N.A.
93.2
38.2
N.A.
89.9
85.7
86.1
84
N.A.
N.A.
N.A.
51.8
73.1
P-Site Identity:
100
100
20
93.3
N.A.
86.6
0
N.A.
66.6
26.6
13.3
26.6
N.A.
N.A.
N.A.
46.6
20
P-Site Similarity:
100
100
20
100
N.A.
100
13.3
N.A.
73.3
46.6
53.3
26.6
N.A.
N.A.
N.A.
60
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.1
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.5
44.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
22
0
29
0
8
8
0
8
8
15
15
58
0
% A
% Cys:
0
0
0
8
8
8
0
0
0
0
0
8
0
8
8
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
8
8
8
43
8
8
0
8
15
8
8
0
29
0
8
% F
% Gly:
0
0
0
8
15
0
50
0
0
36
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
50
8
15
8
0
8
0
8
22
15
0
50
22
8
0
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
8
43
15
15
8
58
15
0
43
15
72
15
22
8
72
% L
% Met:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
8
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
8
0
8
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
15
15
0
8
8
8
8
50
0
8
8
0
0
0
0
% S
% Thr:
0
0
8
0
0
0
0
15
0
0
8
0
8
0
0
% T
% Val:
8
15
29
8
15
8
15
0
8
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% W
% Tyr:
0
15
0
0
0
0
0
0
15
0
0
0
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _