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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HES4
All Species:
39.7
Human Site:
S37
Identified Species:
79.39
UniProt:
Q9HCC6
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HCC6
NP_001135939.1
221
23523
S37
S
A
A
E
H
R
K
S
S
K
P
V
M
E
K
Chimpanzee
Pan troglodytes
XP_001143332
221
23504
S37
S
A
A
E
H
R
K
S
S
K
P
V
M
E
K
Rhesus Macaque
Macaca mulatta
XP_001090404
221
23576
S37
S
A
A
E
H
R
K
S
S
K
P
V
M
E
K
Dog
Lupus familis
XP_546724
225
24255
S37
S
A
A
E
H
R
K
S
S
K
P
V
M
E
K
Cat
Felis silvestris
Mouse
Mus musculus
P35428
282
29730
S37
T
A
S
E
H
R
K
S
S
K
P
I
M
E
K
Rat
Rattus norvegicus
Q04666
281
29603
S37
T
A
S
E
H
R
K
S
S
K
P
I
M
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511924
287
29320
K40
N
E
S
L
S
Q
L
K
T
L
I
L
D
A
L
Chicken
Gallus gallus
O57337
290
31053
S38
S
A
S
E
H
R
K
S
S
K
P
I
M
E
K
Frog
Xenopus laevis
Q90VV1
277
29807
S37
S
A
S
E
H
R
K
S
S
K
P
I
M
E
K
Zebra Danio
Brachydanio rerio
Q9I9L0
324
34311
R49
T
T
S
Q
V
M
A
R
K
K
R
R
G
I
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26263
435
46532
T43
S
K
A
E
L
R
K
T
N
K
P
I
M
E
K
Honey Bee
Apis mellifera
XP_393948
363
38518
S52
R
S
G
E
N
R
R
S
N
K
P
I
M
E
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.8
83.1
N.A.
50
49.8
N.A.
45.9
53.4
52.7
25.9
N.A.
26.8
32.2
N.A.
N.A.
Protein Similarity:
100
100
97.2
86.6
N.A.
60.2
60.1
N.A.
56
62.4
65.3
40.7
N.A.
35.8
41
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
80
80
N.A.
0
86.6
86.6
6.6
N.A.
66.6
53.3
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
33.3
100
100
26.6
N.A.
86.6
86.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
67
42
0
0
0
9
0
0
0
0
0
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% D
% Glu:
0
9
0
84
0
0
0
0
0
0
0
0
0
84
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
0
0
0
0
0
0
0
0
9
0
0
% G
% His:
0
0
0
0
67
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
9
50
0
9
9
% I
% Lys:
0
9
0
0
0
0
75
9
9
92
0
0
0
0
84
% K
% Leu:
0
0
0
9
9
0
9
0
0
9
0
9
0
0
9
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
84
0
0
% M
% Asn:
9
0
0
0
9
0
0
0
17
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
84
0
0
0
0
% P
% Gln:
0
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% Q
% Arg:
9
0
0
0
0
84
9
9
0
0
9
9
0
0
0
% R
% Ser:
59
9
50
0
9
0
0
75
67
0
0
0
0
0
0
% S
% Thr:
25
9
0
0
0
0
0
9
9
0
0
0
0
0
0
% T
% Val:
0
0
0
0
9
0
0
0
0
0
0
34
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _