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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HES4
All Species:
31.52
Human Site:
S69
Identified Species:
63.03
UniProt:
Q9HCC6
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HCC6
NP_001135939.1
221
23523
S69
L
D
A
L
R
K
E
S
S
R
H
S
K
L
E
Chimpanzee
Pan troglodytes
XP_001143332
221
23504
S69
L
D
A
L
R
K
E
S
S
R
H
S
K
L
E
Rhesus Macaque
Macaca mulatta
XP_001090404
221
23576
S69
L
D
A
L
R
K
E
S
S
R
H
S
K
L
E
Dog
Lupus familis
XP_546724
225
24255
S69
L
D
A
F
R
K
D
S
S
R
H
S
K
L
E
Cat
Felis silvestris
Mouse
Mus musculus
P35428
282
29730
S69
L
D
A
L
K
K
D
S
S
R
H
S
K
L
E
Rat
Rattus norvegicus
Q04666
281
29603
S69
L
D
A
L
K
K
D
S
S
R
H
S
K
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511924
287
29320
N72
M
T
V
K
H
L
R
N
L
Q
R
A
Q
M
T
Chicken
Gallus gallus
O57337
290
31053
S70
L
D
A
L
K
K
D
S
S
R
H
S
K
L
E
Frog
Xenopus laevis
Q90VV1
277
29807
S69
L
D
A
L
K
K
D
S
S
R
H
S
K
L
E
Zebra Danio
Brachydanio rerio
Q9I9L0
324
34311
K81
L
V
P
T
A
F
E
K
Q
G
S
A
K
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26263
435
46532
P75
L
E
A
M
K
K
D
P
A
R
H
T
K
L
E
Honey Bee
Apis mellifera
XP_393948
363
38518
P84
L
D
A
M
K
K
D
P
A
R
H
S
K
L
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.8
83.1
N.A.
50
49.8
N.A.
45.9
53.4
52.7
25.9
N.A.
26.8
32.2
N.A.
N.A.
Protein Similarity:
100
100
97.2
86.6
N.A.
60.2
60.1
N.A.
56
62.4
65.3
40.7
N.A.
35.8
41
N.A.
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
0
86.6
86.6
33.3
N.A.
53.3
66.6
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
40
100
100
40
N.A.
93.3
93.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
84
0
9
0
0
0
17
0
0
17
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
75
0
0
0
0
59
0
0
0
0
0
0
0
0
% D
% Glu:
0
9
0
0
0
0
34
0
0
0
0
0
0
0
92
% E
% Phe:
0
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% G
% His:
0
0
0
0
9
0
0
0
0
0
84
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
9
50
84
0
9
0
0
0
0
92
0
0
% K
% Leu:
92
0
0
59
0
9
0
0
9
0
0
0
0
92
0
% L
% Met:
9
0
0
17
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
9
0
0
0
0
17
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
9
9
0
0
9
0
0
% Q
% Arg:
0
0
0
0
34
0
9
0
0
84
9
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
67
67
0
9
75
0
0
0
% S
% Thr:
0
9
0
9
0
0
0
0
0
0
0
9
0
0
9
% T
% Val:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _