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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CWC22 All Species: 32.73
Human Site: S198 Identified Species: 55.38
UniProt: Q9HCG8 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCG8 NP_065994.1 908 105535 S198 V R G R G L L S R S V L Q A Q
Chimpanzee Pan troglodytes XP_001157639 909 105673 S198 V R G R G L L S R S V L Q A Q
Rhesus Macaque Macaca mulatta XP_001100012 907 105697 S198 V R G R G L L S R S V L Q A Q
Dog Lupus familis XP_545549 908 105482 S198 V R G R G L L S R S V L Q A Q
Cat Felis silvestris
Mouse Mus musculus Q8C5N3 908 104755 S196 V R G R G L L S R S V L Q A Q
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515527 921 106628 S206 V R G R G L L S R S I L Q A Q
Chicken Gallus gallus Q5ZKA3 926 108657 S204 V R G R G L L S R S I L Q A Q
Frog Xenopus laevis Q52KN9 803 92701 D170 K K K K E E L D P I L T R T G
Zebra Danio Brachydanio rerio Q08C72 985 113331 A292 V R G R G L L A R S I L Q A Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VJ87 1330 151618 S455 V R G R G L L S R S I I Q A Q
Honey Bee Apis mellifera XP_001120152 706 80124 S73 H I F S I E K S G A A Y Q R I
Nematode Worm Caenorhab. elegans Q17336 897 104250 C229 I R S K G L L C R D I I Q A Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53333 577 67276
Red Bread Mold Neurospora crassa Q7RX84 1010 113982 C257 I R G R G L F C Q S L L K A Q
Conservation
Percent
Protein Identity: 100 99.2 97.2 93.2 N.A. 84.2 N.A. N.A. 77.5 70.6 67.1 60.9 N.A. 39.8 45.5 45.9 N.A.
Protein Similarity: 100 99.4 98.4 95.6 N.A. 90 N.A. N.A. 86.5 80.2 74.6 71.8 N.A. 52.1 58.9 65.7 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 N.A. N.A. 93.3 93.3 6.6 86.6 N.A. 86.6 13.3 53.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 100 100 33.3 100 N.A. 100 20 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.2 38.9
Protein Similarity: N.A. N.A. N.A. N.A. 38.9 55.5
P-Site Identity: N.A. N.A. N.A. N.A. 0 60
P-Site Similarity: N.A. N.A. N.A. N.A. 0 86.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 8 0 8 8 0 0 79 0 % A
% Cys: 0 0 0 0 0 0 0 15 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % D
% Glu: 0 0 0 0 8 15 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 8 0 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 72 0 79 0 0 0 8 0 0 0 0 0 8 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 15 8 0 0 8 0 0 0 0 8 36 15 0 0 8 % I
% Lys: 8 8 8 15 0 0 8 0 0 0 0 0 8 0 0 % K
% Leu: 0 0 0 0 0 79 79 0 0 0 15 65 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 0 0 79 0 79 % Q
% Arg: 0 79 0 72 0 0 0 0 72 0 0 0 8 8 0 % R
% Ser: 0 0 8 8 0 0 0 65 0 72 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 8 0 8 0 % T
% Val: 65 0 0 0 0 0 0 0 0 0 36 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _