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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CWC22 All Species: 24.55
Human Site: S703 Identified Species: 41.54
UniProt: Q9HCG8 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCG8 NP_065994.1 908 105535 S703 S S S E E S D S S S I S S H S
Chimpanzee Pan troglodytes XP_001157639 909 105673 S704 S S S E E S D S S S I S S H S
Rhesus Macaque Macaca mulatta XP_001100012 907 105697 S703 S S S E E S D S S S I S S H S
Dog Lupus familis XP_545549 908 105482 S703 S S S E E S D S S S S S S Q S
Cat Felis silvestris
Mouse Mus musculus Q8C5N3 908 104755 Q708 S S S S S S T Q S S T S G I T
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515527 921 106628 T717 S S S T S G R T Q E E S A A I
Chicken Gallus gallus Q5ZKA3 926 108657 S706 S S S S S D S S D S D A S K A
Frog Xenopus laevis Q52KN9 803 92701 L617 S V L E C M N L S E E T T T S
Zebra Danio Brachydanio rerio Q08C72 985 113331 S796 S S S D S D S S S S S G S S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VJ87 1330 151618 S968 D S S S D S S S E S S S S D S
Honey Bee Apis mellifera XP_001120152 706 80124 N520 Y M G L S K L N Q R V K D I T
Nematode Worm Caenorhab. elegans Q17336 897 104250 S707 S S S S S D S S D S S D S S D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53333 577 67276 L391 L G K F W G H L I S Y E F L P
Red Bread Mold Neurospora crassa Q7RX84 1010 113982 G757 S R T P P R R G R G R S Y S R
Conservation
Percent
Protein Identity: 100 99.2 97.2 93.2 N.A. 84.2 N.A. N.A. 77.5 70.6 67.1 60.9 N.A. 39.8 45.5 45.9 N.A.
Protein Similarity: 100 99.4 98.4 95.6 N.A. 90 N.A. N.A. 86.5 80.2 74.6 71.8 N.A. 52.1 58.9 65.7 N.A.
P-Site Identity: 100 100 100 86.6 N.A. 46.6 N.A. N.A. 26.6 40 26.6 53.3 N.A. 53.3 0 40 N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 53.3 N.A. N.A. 40 53.3 46.6 60 N.A. 60 20 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.2 38.9
Protein Similarity: N.A. N.A. N.A. N.A. 38.9 55.5
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 8 8 8 8 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 8 8 22 29 0 15 0 8 8 8 8 8 % D
% Glu: 0 0 0 36 29 0 0 0 8 15 15 8 0 0 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 0 % F
% Gly: 0 8 8 0 0 15 0 8 0 8 0 8 8 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 22 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 22 0 0 15 8 % I
% Lys: 0 0 8 0 0 8 0 0 0 0 0 8 0 8 0 % K
% Leu: 8 0 8 8 0 0 8 15 0 0 0 0 0 8 0 % L
% Met: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 8 % P
% Gln: 0 0 0 0 0 0 0 8 15 0 0 0 0 8 0 % Q
% Arg: 0 8 0 0 0 8 15 0 8 8 8 0 0 0 8 % R
% Ser: 79 72 72 29 43 43 29 58 50 72 29 58 58 22 50 % S
% Thr: 0 0 8 8 0 0 8 8 0 0 8 8 8 8 15 % T
% Val: 0 8 0 0 0 0 0 0 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 8 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _