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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CWC22 All Species: 21.21
Human Site: S727 Identified Species: 35.9
UniProt: Q9HCG8 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCG8 NP_065994.1 908 105535 S727 K G H G K T R S K E V D K L I
Chimpanzee Pan troglodytes XP_001157639 909 105673 S728 K G H G K T R S K E V D K L I
Rhesus Macaque Macaca mulatta XP_001100012 907 105697 S727 K G H G K T R S K E V D K L I
Dog Lupus familis XP_545549 908 105482 S727 K G Q G N S R S K E V D K L I
Cat Felis silvestris
Mouse Mus musculus Q8C5N3 908 104755 G732 K R Q G K A R G E E V D K L A
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515527 921 106628 S741 K V E R K K K S K E A D K V T
Chicken Gallus gallus Q5ZKA3 926 108657 R730 R E S D K A S R K K Q E K K R
Frog Xenopus laevis Q52KN9 803 92701 M641 F Q E L C E Y M G L P K L N A
Zebra Danio Brachydanio rerio Q08C72 985 113331 S820 S G K K K D K S K S K K S S K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VJ87 1330 151618 K992 R K D K D K K K S K K A T K E
Honey Bee Apis mellifera XP_001120152 706 80124 T544 P R D D P K N T R F A I N F F
Nematode Worm Caenorhab. elegans Q17336 897 104250 S731 D S S S S S E S E P E P P K K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53333 577 67276 Q415 T E E E S C P Q G R I F I K F
Red Bread Mold Neurospora crassa Q7RX84 1010 113982 S781 R S Y S R S V S K S V S R S P
Conservation
Percent
Protein Identity: 100 99.2 97.2 93.2 N.A. 84.2 N.A. N.A. 77.5 70.6 67.1 60.9 N.A. 39.8 45.5 45.9 N.A.
Protein Similarity: 100 99.4 98.4 95.6 N.A. 90 N.A. N.A. 86.5 80.2 74.6 71.8 N.A. 52.1 58.9 65.7 N.A.
P-Site Identity: 100 100 100 80 N.A. 60 N.A. N.A. 46.6 20 0 26.6 N.A. 0 0 6.6 N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 66.6 N.A. N.A. 60 40 0 33.3 N.A. 20 13.3 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.2 38.9
Protein Similarity: N.A. N.A. N.A. N.A. 38.9 55.5
P-Site Identity: N.A. N.A. N.A. N.A. 0 20
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 53.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 15 0 0 0 0 15 8 0 0 15 % A
% Cys: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 15 15 8 8 0 0 0 0 0 43 0 0 0 % D
% Glu: 0 15 22 8 0 8 8 0 15 43 8 8 0 0 8 % E
% Phe: 8 0 0 0 0 0 0 0 0 8 0 8 0 8 15 % F
% Gly: 0 36 0 36 0 0 0 8 15 0 0 0 0 0 0 % G
% His: 0 0 22 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 8 8 8 0 29 % I
% Lys: 43 8 8 15 50 22 22 8 58 15 15 15 50 29 15 % K
% Leu: 0 0 0 8 0 0 0 0 0 8 0 0 8 36 0 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 8 0 0 0 0 0 8 8 0 % N
% Pro: 8 0 0 0 8 0 8 0 0 8 8 8 8 0 8 % P
% Gln: 0 8 15 0 0 0 0 8 0 0 8 0 0 0 0 % Q
% Arg: 22 15 0 8 8 0 36 8 8 8 0 0 8 0 8 % R
% Ser: 8 15 15 15 15 22 8 58 8 15 0 8 8 15 0 % S
% Thr: 8 0 0 0 0 22 0 8 0 0 0 0 8 0 8 % T
% Val: 0 8 0 0 0 0 8 0 0 0 43 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 8 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _