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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CWC22 All Species: 38.18
Human Site: Y154 Identified Species: 64.62
UniProt: Q9HCG8 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCG8 NP_065994.1 908 105535 Y154 T D K N S L A Y Q R M S W E A
Chimpanzee Pan troglodytes XP_001157639 909 105673 Y154 T D K N S L A Y Q R M S W E A
Rhesus Macaque Macaca mulatta XP_001100012 907 105697 Y154 T D K N S L A Y Q R M S W E A
Dog Lupus familis XP_545549 908 105482 Y154 T D K N S L A Y Q R M S W E A
Cat Felis silvestris
Mouse Mus musculus Q8C5N3 908 104755 R154 K S S L A Y Q R M S W E A L K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515527 921 106628 Y162 T D K N S L A Y Q R M S W E A
Chicken Gallus gallus Q5ZKA3 926 108657 Y160 T D K N S L A Y Q R M S W E A
Frog Xenopus laevis Q52KN9 803 92701 D130 R Q N Y Q D R D Y E K R S P P
Zebra Danio Brachydanio rerio Q08C72 985 113331 Y248 T D K S S L E Y Q R M S W E A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VJ87 1330 151618 Y411 T D K S S A A Y Q R I A W E A
Honey Bee Apis mellifera XP_001120152 706 80124 G33 T E M K T R L G Q F K Y D C F
Nematode Worm Caenorhab. elegans Q17336 897 104250 Y185 S D K Q S E Q Y Q R M N W E R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53333 577 67276
Red Bread Mold Neurospora crassa Q7RX84 1010 113982 Y213 T D K K T R E Y Q R M A W E A
Conservation
Percent
Protein Identity: 100 99.2 97.2 93.2 N.A. 84.2 N.A. N.A. 77.5 70.6 67.1 60.9 N.A. 39.8 45.5 45.9 N.A.
Protein Similarity: 100 99.4 98.4 95.6 N.A. 90 N.A. N.A. 86.5 80.2 74.6 71.8 N.A. 52.1 58.9 65.7 N.A.
P-Site Identity: 100 100 100 100 N.A. 0 N.A. N.A. 100 100 0 86.6 N.A. 73.3 13.3 60 N.A.
P-Site Similarity: 100 100 100 100 N.A. 6.6 N.A. N.A. 100 100 0 93.3 N.A. 93.3 26.6 73.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.2 38.9
Protein Similarity: N.A. N.A. N.A. N.A. 38.9 55.5
P-Site Identity: N.A. N.A. N.A. N.A. 0 66.6
P-Site Similarity: N.A. N.A. N.A. N.A. 0 80
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 8 50 0 0 0 0 15 8 0 65 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 72 0 0 0 8 0 8 0 0 0 0 8 0 0 % D
% Glu: 0 8 0 0 0 8 15 0 0 8 0 8 0 72 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % F
% Gly: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % I
% Lys: 8 0 72 15 0 0 0 0 0 0 15 0 0 0 8 % K
% Leu: 0 0 0 8 0 50 8 0 0 0 0 0 0 8 0 % L
% Met: 0 0 8 0 0 0 0 0 8 0 65 0 0 0 0 % M
% Asn: 0 0 8 43 0 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 8 % P
% Gln: 0 8 0 8 8 0 15 0 79 0 0 0 0 0 0 % Q
% Arg: 8 0 0 0 0 15 8 8 0 72 0 8 0 0 8 % R
% Ser: 8 8 8 15 65 0 0 0 0 8 0 50 8 0 0 % S
% Thr: 72 0 0 0 15 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 72 0 0 % W
% Tyr: 0 0 0 8 0 8 0 72 8 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _