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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2C4 All Species: 24.24
Human Site: S375 Identified Species: 44.44
UniProt: Q9HCK5 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCK5 NP_060099.2 861 97097 S375 E I S R L V K S N S M V G G P
Chimpanzee Pan troglodytes XP_524663 1051 117595 S565 E I S R L V K S N S M V G G P
Rhesus Macaque Macaca mulatta XP_001100725 1053 117937 M577 E I S K L V S M R S A S F N T
Dog Lupus familis XP_539597 877 99324 S391 E I S R L V K S N S M V G G P
Cat Felis silvestris
Mouse Mus musculus Q8CJF8 861 97018 S375 E I S R L V K S N S M V G G P
Rat Rattus norvegicus Q9QZ81 860 97300 M384 Q E E I S K L M R S A S F N T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510187 878 98879 S392 E I S R L V K S N S M V G G P
Chicken Gallus gallus Q5ZMW0 794 89512 P339 E L T G R V L P A P M L Q Y G
Frog Xenopus laevis Q4KLV6 884 99519 S398 E I S R L V K S N S M V G G P
Zebra Danio Brachydanio rerio A3KPK0 860 97313 V384 Q E E I S R L V R S A N Y N S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUQ5 1214 136831 S705 N V G S S I K S I L L P I E L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34681 1040 115397 A521 E D R I K Q L A A Q A S F G T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04379 1048 116172 L538 D I L Q T V Q L N D Y A K D N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 81.9 63.2 97.4 N.A. 98.8 78.4 N.A. 97.3 91.7 94.9 81.4 N.A. 20.1 N.A. 31.9 N.A.
Protein Similarity: 100 81.9 72.1 97.6 N.A. 99.7 88.6 N.A. 97.6 92 96.6 89.7 N.A. 33.7 N.A. 49.7 N.A.
P-Site Identity: 100 100 40 100 N.A. 100 6.6 N.A. 100 20 100 6.6 N.A. 13.3 N.A. 13.3 N.A.
P-Site Similarity: 100 100 46.6 100 N.A. 100 13.3 N.A. 100 40 100 13.3 N.A. 33.3 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 36.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 53.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 8 16 0 31 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 8 0 0 0 0 0 0 0 8 0 0 0 8 0 % D
% Glu: 70 16 16 0 0 0 0 0 0 0 0 0 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 24 0 0 % F
% Gly: 0 0 8 8 0 0 0 0 0 0 0 0 47 54 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 62 0 24 0 8 0 0 8 0 0 0 8 0 0 % I
% Lys: 0 0 0 8 8 8 54 0 0 0 0 0 8 0 0 % K
% Leu: 0 8 8 0 54 0 31 8 0 8 8 8 0 0 8 % L
% Met: 0 0 0 0 0 0 0 16 0 0 54 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 54 0 0 8 0 24 8 % N
% Pro: 0 0 0 0 0 0 0 8 0 8 0 8 0 0 47 % P
% Gln: 16 0 0 8 0 8 8 0 0 8 0 0 8 0 0 % Q
% Arg: 0 0 8 47 8 8 0 0 24 0 0 0 0 0 0 % R
% Ser: 0 0 54 8 24 0 8 54 0 70 0 24 0 0 8 % S
% Thr: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 24 % T
% Val: 0 8 0 0 0 70 0 8 0 0 0 47 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 8 0 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _