Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2C4 All Species: 35.45
Human Site: S765 Identified Species: 65
UniProt: Q9HCK5 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCK5 NP_060099.2 861 97097 S765 I Q G T S R P S H Y Q V L W D
Chimpanzee Pan troglodytes XP_524663 1051 117595 S955 I Q G T S R P S H Y Q V L W D
Rhesus Macaque Macaca mulatta XP_001100725 1053 117937 S957 I Q G T S R P S H Y H V L W D
Dog Lupus familis XP_539597 877 99324 S781 I Q G T S R P S H Y Q V L W D
Cat Felis silvestris
Mouse Mus musculus Q8CJF8 861 97018 S765 I Q G T S R P S H Y Q V L W D
Rat Rattus norvegicus Q9QZ81 860 97300 S764 I Q G T S R P S H Y H V L W D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510187 878 98879 S782 I Q G T S R P S H Y Q V L W D
Chicken Gallus gallus Q5ZMW0 794 89512 V702 S R P S H Y Q V L W D D N C F
Frog Xenopus laevis Q4KLV6 884 99519 S788 I Q G T S R P S H Y Q V L W D
Zebra Danio Brachydanio rerio A3KPK0 860 97313 S764 I Q G T S R P S H Y Y V L W D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUQ5 1214 136831 N1110 D R T I V H P N E M Q F F M V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34681 1040 115397 A911 V Q G T S R P A R Y H V L L D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04379 1048 116172 A942 I Q G T S R P A H Y H V L W D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 81.9 63.2 97.4 N.A. 98.8 78.4 N.A. 97.3 91.7 94.9 81.4 N.A. 20.1 N.A. 31.9 N.A.
Protein Similarity: 100 81.9 72.1 97.6 N.A. 99.7 88.6 N.A. 97.6 92 96.6 89.7 N.A. 33.7 N.A. 49.7 N.A.
P-Site Identity: 100 100 93.3 100 N.A. 100 93.3 N.A. 100 0 100 93.3 N.A. 13.3 N.A. 66.6 N.A.
P-Site Similarity: 100 100 93.3 100 N.A. 100 93.3 N.A. 100 20 100 93.3 N.A. 26.6 N.A. 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 36.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 53.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 86.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 93.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 16 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 8 0 0 0 0 0 0 0 0 0 8 8 0 0 85 % D
% Glu: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 8 % F
% Gly: 0 0 85 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 8 8 0 0 77 0 31 0 0 0 0 % H
% Ile: 77 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 8 0 0 0 85 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 8 0 % M
% Asn: 0 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % N
% Pro: 0 0 8 0 0 0 93 0 0 0 0 0 0 0 0 % P
% Gln: 0 85 0 0 0 0 8 0 0 0 54 0 0 0 0 % Q
% Arg: 0 16 0 0 0 85 0 0 8 0 0 0 0 0 0 % R
% Ser: 8 0 0 8 85 0 0 70 0 0 0 0 0 0 0 % S
% Thr: 0 0 8 85 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 8 0 0 0 8 0 0 8 0 0 0 85 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 77 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 85 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _