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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHD8 All Species: 27.27
Human Site: S1272 Identified Species: 50
UniProt: Q9HCK8 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCK8 NP_065971.2 2581 290518 S1272 R E M F D K A S L K L G L D K
Chimpanzee Pan troglodytes XP_001153522 2556 287735 S1247 R E M F D K A S L K L G L D K
Rhesus Macaque Macaca mulatta XP_001096619 2585 291342 S1277 R E M F D K A S L K L G L D K
Dog Lupus familis XP_532624 2304 262413 D1157 R P R S R R H D R H H T Y G R
Cat Felis silvestris
Mouse Mus musculus Q09XV5 2582 290829 S1274 R E M F D K A S L K L G L D K
Rat Rattus norvegicus Q9JIX5 2581 290674 S1272 R E M F D K A S L K L G L D K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512847 2876 321833 S1321 R E M F D R A S L K L G L D K
Chicken Gallus gallus Q06A37 3011 338194 S1430 R E M F D K A S L K L G L D K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio B0R0I6 2511 279693 K1307 Y E R E M L D K A S L K L G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KU24 1883 211809 F795 K R G S T S T F L N I V I E L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22516 1787 205237 D699 Y V V T Y V G D R E S R M V I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S775 1384 158387 L296 S K Q T H V I L A D E M G L G
Baker's Yeast Sacchar. cerevisiae P32657 1468 168223 Q380 G G E L R D F Q L T G I N W M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 97 87.8 N.A. 96.1 96.3 N.A. 48.5 43.4 N.A. 56.7 N.A. 23.9 N.A. 23 N.A.
Protein Similarity: 100 98.9 97.5 88.3 N.A. 97.8 97.8 N.A. 62 57 N.A. 68.6 N.A. 39.3 N.A. 37.6 N.A.
P-Site Identity: 100 100 100 6.6 N.A. 100 100 N.A. 93.3 100 N.A. 20 N.A. 6.6 N.A. 0 N.A.
P-Site Similarity: 100 100 100 20 N.A. 100 100 N.A. 100 100 N.A. 20 N.A. 33.3 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20.9 21.5 N.A.
Protein Similarity: N.A. N.A. N.A. 34.3 36 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 54 0 16 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 54 8 8 16 0 8 0 0 0 54 0 % D
% Glu: 0 62 8 8 0 0 0 0 0 8 8 0 0 8 0 % E
% Phe: 0 0 0 54 0 0 8 8 0 0 0 0 0 0 0 % F
% Gly: 8 8 8 0 0 0 8 0 0 0 8 54 8 16 8 % G
% His: 0 0 0 0 8 0 8 0 0 8 8 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 0 0 8 8 8 0 8 % I
% Lys: 8 8 0 0 0 47 0 8 0 54 0 8 0 0 54 % K
% Leu: 0 0 0 8 0 8 0 8 70 0 62 0 62 8 16 % L
% Met: 0 0 54 0 8 0 0 0 0 0 0 8 8 0 8 % M
% Asn: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 0 % N
% Pro: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 8 0 0 0 0 8 0 0 0 0 0 0 0 % Q
% Arg: 62 8 16 0 16 16 0 0 16 0 0 8 0 0 8 % R
% Ser: 8 0 0 16 0 8 0 54 0 8 8 0 0 0 0 % S
% Thr: 0 0 0 16 8 0 8 0 0 8 0 8 0 0 0 % T
% Val: 0 8 8 0 0 16 0 0 0 0 0 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 16 0 0 0 8 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _