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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHD8 All Species: 16.36
Human Site: S2018 Identified Species: 30
UniProt: Q9HCK8 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCK8 NP_065971.2 2581 290518 S2018 E T A T Q V P S L E S L T L K
Chimpanzee Pan troglodytes XP_001153522 2556 287735 S1993 E T A T Q V P S L E S L T L K
Rhesus Macaque Macaca mulatta XP_001096619 2585 291342 S2023 E T A A Q V P S L E S L T L K
Dog Lupus familis XP_532624 2304 262413 S1776 S D T T P L V S R N V P P V K
Cat Felis silvestris
Mouse Mus musculus Q09XV5 2582 290829 N2020 E S T V Q V P N L E S L T L K
Rat Rattus norvegicus Q9JIX5 2581 290674 S2018 E N A V Q V P S L D S L T L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512847 2876 321833 E2055 K N E T L K E E P P S S E A E
Chicken Gallus gallus Q06A37 3011 338194 A2185 V E G S E N P A A K E K S D I
Frog Xenopus laevis
Zebra Danio Brachydanio rerio B0R0I6 2511 279693 L2015 Y S F S Q S R L D Y L Q N Q Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KU24 1883 211809 S1412 A N D A K A A S Q S A S S T I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22516 1787 205237 P1316 I E V L G F N P R Q R K A F Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S775 1384 158387 G913 Y E A E S T D G E A A G Q G V
Baker's Yeast Sacchar. cerevisiae P32657 1468 168223 S997 D D D S T S R S S R R R A R A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 97 87.8 N.A. 96.1 96.3 N.A. 48.5 43.4 N.A. 56.7 N.A. 23.9 N.A. 23 N.A.
Protein Similarity: 100 98.9 97.5 88.3 N.A. 97.8 97.8 N.A. 62 57 N.A. 68.6 N.A. 39.3 N.A. 37.6 N.A.
P-Site Identity: 100 100 93.3 20 N.A. 73.3 80 N.A. 13.3 6.6 N.A. 6.6 N.A. 6.6 N.A. 0 N.A.
P-Site Similarity: 100 100 93.3 33.3 N.A. 86.6 86.6 N.A. 26.6 40 N.A. 26.6 N.A. 26.6 N.A. 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20.9 21.5 N.A.
Protein Similarity: N.A. N.A. N.A. 34.3 36 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 39 16 0 8 8 8 8 8 16 0 16 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 16 16 0 0 0 8 0 8 8 0 0 0 8 0 % D
% Glu: 39 24 8 8 8 0 8 8 8 31 8 0 8 0 8 % E
% Phe: 0 0 8 0 0 8 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 0 8 0 8 0 0 8 0 0 0 8 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 16 % I
% Lys: 8 0 0 0 8 8 0 0 0 8 0 16 0 0 47 % K
% Leu: 0 0 0 8 8 8 0 8 39 0 8 39 0 39 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 24 0 0 0 8 8 8 0 8 0 0 8 0 0 % N
% Pro: 0 0 0 0 8 0 47 8 8 8 0 8 8 0 0 % P
% Gln: 0 0 0 0 47 0 0 0 8 8 0 8 8 8 8 % Q
% Arg: 0 0 0 0 0 0 16 0 16 8 16 8 0 8 0 % R
% Ser: 8 16 0 24 8 16 0 54 8 8 47 16 16 0 0 % S
% Thr: 0 24 16 31 8 8 0 0 0 0 0 0 39 8 0 % T
% Val: 8 0 8 16 0 39 8 0 0 0 8 0 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 16 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _