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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHD8 All Species: 19.7
Human Site: S2200 Identified Species: 36.11
UniProt: Q9HCK8 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCK8 NP_065971.2 2581 290518 S2200 P G N H L L D S P S L T P G E
Chimpanzee Pan troglodytes XP_001153522 2556 287735 S2175 P G N H L L D S P S L T P G E
Rhesus Macaque Macaca mulatta XP_001096619 2585 291342 S2205 P G N H L L D S P S L T P G E
Dog Lupus familis XP_532624 2304 262413 A1953 M A E E E V S A V T T A A A Q
Cat Felis silvestris
Mouse Mus musculus Q09XV5 2582 290829 S2202 P G N H L L D S P S L T P G E
Rat Rattus norvegicus Q9JIX5 2581 290674 S2200 P G N H L L D S P S L T P G E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512847 2876 321833 D2304 F Y T T K L L D S P G A A A D
Chicken Gallus gallus Q06A37 3011 338194 S2364 D S P L Q K R S F A E L S M I
Frog Xenopus laevis
Zebra Danio Brachydanio rerio B0R0I6 2511 279693 H2194 C S L V I T G H W P S G R R Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KU24 1883 211809 L1588 T E L D A K R L F K I Y K H A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22516 1787 205237 Y1492 F N I C D G G Y T E L H S L W
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S775 1384 158387 W1089 L K H G Y G R W Q A I V D D K
Baker's Yeast Sacchar. cerevisiae P32657 1468 168223 S1173 K P V Q N W S S N W T K E E D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 97 87.8 N.A. 96.1 96.3 N.A. 48.5 43.4 N.A. 56.7 N.A. 23.9 N.A. 23 N.A.
Protein Similarity: 100 98.9 97.5 88.3 N.A. 97.8 97.8 N.A. 62 57 N.A. 68.6 N.A. 39.3 N.A. 37.6 N.A.
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. 6.6 6.6 N.A. 0 N.A. 0 N.A. 6.6 N.A.
P-Site Similarity: 100 100 100 26.6 N.A. 100 100 N.A. 13.3 13.3 N.A. 6.6 N.A. 6.6 N.A. 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20.9 21.5 N.A.
Protein Similarity: N.A. N.A. N.A. 34.3 36 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 8 0 0 8 0 16 0 16 16 16 8 % A
% Cys: 8 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 8 8 0 39 8 0 0 0 0 8 8 16 % D
% Glu: 0 8 8 8 8 0 0 0 0 8 8 0 8 8 39 % E
% Phe: 16 0 0 0 0 0 0 0 16 0 0 0 0 0 0 % F
% Gly: 0 39 0 8 0 16 16 0 0 0 8 8 0 39 0 % G
% His: 0 0 8 39 0 0 0 8 0 0 0 8 0 8 0 % H
% Ile: 0 0 8 0 8 0 0 0 0 0 16 0 0 0 8 % I
% Lys: 8 8 0 0 8 16 0 0 0 8 0 8 8 0 8 % K
% Leu: 8 0 16 8 39 47 8 8 0 0 47 8 0 8 0 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 8 39 0 8 0 0 0 8 0 0 0 0 0 0 % N
% Pro: 39 8 8 0 0 0 0 0 39 16 0 0 39 0 0 % P
% Gln: 0 0 0 8 8 0 0 0 8 0 0 0 0 0 8 % Q
% Arg: 0 0 0 0 0 0 24 0 0 0 0 0 8 8 0 % R
% Ser: 0 16 0 0 0 0 16 54 8 39 8 0 16 0 0 % S
% Thr: 8 0 8 8 0 8 0 0 8 8 16 39 0 0 0 % T
% Val: 0 0 8 8 0 8 0 0 8 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 8 0 8 8 8 0 0 0 0 8 % W
% Tyr: 0 8 0 0 8 0 0 8 0 0 0 8 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _