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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHD8 All Species: 18.18
Human Site: S506 Identified Species: 33.33
UniProt: Q9HCK8 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCK8 NP_065971.2 2581 290518 S506 E K K R R K K S A G E R L K E
Chimpanzee Pan troglodytes XP_001153522 2556 287735 S481 E K K R R K K S A G E R L K E
Rhesus Macaque Macaca mulatta XP_001096619 2585 291342 S511 E K K R R K K S A G E R L K E
Dog Lupus familis XP_532624 2304 262413 H455 D R I L D E S H S I D K D N G
Cat Felis silvestris
Mouse Mus musculus Q09XV5 2582 290829 S508 E K K R R K K S S G E R L K E
Rat Rattus norvegicus Q9JIX5 2581 290674 S506 E K K R R K K S S G E R L K E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512847 2876 321833 I528 Q E K A N R I I S E A I A K A
Chicken Gallus gallus Q06A37 3011 338194 K653 K K K K K K P K A K K E P K D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio B0R0I6 2511 279693 M537 P S A G G A K M V V G G D K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KU24 1883 211809 D107 S G S D S D S D A E G P S D Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22516 1787 205237 G11 D Q H E S I D G D E T M E E D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S775 1384 158387
Baker's Yeast Sacchar. cerevisiae P32657 1468 168223
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 97 87.8 N.A. 96.1 96.3 N.A. 48.5 43.4 N.A. 56.7 N.A. 23.9 N.A. 23 N.A.
Protein Similarity: 100 98.9 97.5 88.3 N.A. 97.8 97.8 N.A. 62 57 N.A. 68.6 N.A. 39.3 N.A. 37.6 N.A.
P-Site Identity: 100 100 100 0 N.A. 93.3 93.3 N.A. 13.3 33.3 N.A. 13.3 N.A. 6.6 N.A. 0 N.A.
P-Site Similarity: 100 100 100 40 N.A. 100 100 N.A. 40 66.6 N.A. 20 N.A. 13.3 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20.9 21.5 N.A.
Protein Similarity: N.A. N.A. N.A. 34.3 36 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 8 0 8 0 0 39 0 8 0 8 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 0 0 8 8 8 8 8 8 0 8 0 16 8 16 % D
% Glu: 39 8 0 8 0 8 0 0 0 24 39 8 8 8 39 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 8 8 0 0 8 0 39 16 8 0 0 8 % G
% His: 0 0 8 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 8 8 8 0 8 0 8 0 0 0 % I
% Lys: 8 47 54 8 8 47 47 8 0 8 8 8 0 62 8 % K
% Leu: 0 0 0 8 0 0 0 0 0 0 0 0 39 0 0 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 8 0 0 0 0 0 8 0 0 0 0 8 8 0 0 % P
% Gln: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 8 % Q
% Arg: 0 8 0 39 39 8 0 0 0 0 0 39 0 0 0 % R
% Ser: 8 8 8 0 16 0 16 39 31 0 0 0 8 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _