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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHD8 All Species: 23.94
Human Site: Y2516 Identified Species: 43.89
UniProt: Q9HCK8 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCK8 NP_065971.2 2581 290518 Y2516 P G L R A P G Y P S S P V T T
Chimpanzee Pan troglodytes XP_001153522 2556 287735 Y2491 P G L R A P G Y P S S P A T T
Rhesus Macaque Macaca mulatta XP_001096619 2585 291342 Y2521 P G L R A P G Y P S S P A T T
Dog Lupus familis XP_532624 2304 262413 Y2238 P G L R A T G Y P S S P A T T
Cat Felis silvestris
Mouse Mus musculus Q09XV5 2582 290829 Y2517 P G L R T T G Y P S S P A T T
Rat Rattus norvegicus Q9JIX5 2581 290674 Y2516 P G L R T T G Y P S S P A T T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512847 2876 321833 S2808 N I F D V Q N S K N S D L G S
Chicken Gallus gallus Q06A37 3011 338194 T2884 S A A T A A T T A T A T T T T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio B0R0I6 2511 279693 H2450 E D L E D G G H L T S S H H F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KU24 1883 211809 Y1827 S G L P P H P Y S S H Y L P P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22516 1787 205237 N1731 F P S L F D C N L S P D D E P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S775 1384 158387 N1328 D D T K P D L N N V E M K D T
Baker's Yeast Sacchar. cerevisiae P32657 1468 168223 L1412 A K I L K T E L T T I G N H I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 97 87.8 N.A. 96.1 96.3 N.A. 48.5 43.4 N.A. 56.7 N.A. 23.9 N.A. 23 N.A.
Protein Similarity: 100 98.9 97.5 88.3 N.A. 97.8 97.8 N.A. 62 57 N.A. 68.6 N.A. 39.3 N.A. 37.6 N.A.
P-Site Identity: 100 93.3 93.3 86.6 N.A. 80 80 N.A. 6.6 20 N.A. 20 N.A. 26.6 N.A. 6.6 N.A.
P-Site Similarity: 100 93.3 93.3 86.6 N.A. 80 80 N.A. 26.6 33.3 N.A. 33.3 N.A. 33.3 N.A. 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20.9 21.5 N.A.
Protein Similarity: N.A. N.A. N.A. 34.3 36 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 39 8 0 0 8 0 8 0 39 0 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 8 16 0 8 8 16 0 0 0 0 0 16 8 8 0 % D
% Glu: 8 0 0 8 0 0 8 0 0 0 8 0 0 8 0 % E
% Phe: 8 0 8 0 8 0 0 0 0 0 0 0 0 0 8 % F
% Gly: 0 54 0 0 0 8 54 0 0 0 0 8 0 8 0 % G
% His: 0 0 0 0 0 8 0 8 0 0 8 0 8 16 0 % H
% Ile: 0 8 8 0 0 0 0 0 0 0 8 0 0 0 8 % I
% Lys: 0 8 0 8 8 0 0 0 8 0 0 0 8 0 0 % K
% Leu: 0 0 62 16 0 0 8 8 16 0 0 0 16 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 8 0 0 0 0 0 8 16 8 8 0 0 8 0 0 % N
% Pro: 47 8 0 8 16 24 8 0 47 0 8 47 0 8 16 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 47 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 16 0 8 0 0 0 0 8 8 62 62 8 0 0 8 % S
% Thr: 0 0 8 8 16 31 8 8 8 24 0 8 8 54 62 % T
% Val: 0 0 0 0 8 0 0 0 0 8 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 54 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _