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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE11A All Species: 22.73
Human Site: S239 Identified Species: 41.67
UniProt: Q9HCR9 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCR9 NP_001070664.1 934 104811 S239 M V D A D R C S L F L V E G A
Chimpanzee Pan troglodytes XP_001154733 931 104409 S239 M V D A D R C S L F L V E G A
Rhesus Macaque Macaca mulatta XP_001097592 933 104746 S239 M V D A D R C S L F L V E R A
Dog Lupus familis XP_545544 1009 112832 S232 M V D A D R C S L F L V E G A
Cat Felis silvestris
Mouse Mus musculus P0C1Q2 933 104545 S239 M V D A D R C S L F L V E G A
Rat Rattus norvegicus Q8VID6 935 104553 S239 M V D A D R C S L F L V E G A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515351 961 106911 G264 M P I R N S D G E I I G V A Q
Chicken Gallus gallus P52731 862 99990 V223 Y L N F I S L V L R N H H T S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_689838 865 97719 D226 L P S L S N S D E V Q V P W G
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 G230 V L P S M N S G E V Q V P W G
Fruit Fly Dros. melanogaster Q9VJ79 1451 160911 L442 L N A D R G S L F L V Q G R C
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P91119 710 81117 T71 K R R V I L E T S D N R T R I
Sea Urchin Strong. purpuratus XP_001185423 1005 112913 G324 V E L F L L E G P K G K E V L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.3 86.3 N.A. 94.5 93.9 N.A. 77.4 24.1 N.A. 77.8 80.7 30.5 N.A. 27.5 45.7
Protein Similarity: 100 99 99.3 88.5 N.A. 96.4 96.2 N.A. 82.7 45.1 N.A. 83.7 86.8 42.5 N.A. 45.6 61.1
P-Site Identity: 100 100 93.3 100 N.A. 100 100 N.A. 6.6 6.6 N.A. 6.6 6.6 0 N.A. 0 6.6
P-Site Similarity: 100 100 93.3 100 N.A. 100 100 N.A. 20 26.6 N.A. 13.3 26.6 13.3 N.A. 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 47 0 0 0 0 0 0 0 0 0 8 47 % A
% Cys: 0 0 0 0 0 0 47 0 0 0 0 0 0 0 8 % C
% Asp: 0 0 47 8 47 0 8 8 0 8 0 0 0 0 0 % D
% Glu: 0 8 0 0 0 0 16 0 24 0 0 0 54 0 0 % E
% Phe: 0 0 0 16 0 0 0 0 8 47 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 0 24 0 0 8 8 8 39 16 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 0 % H
% Ile: 0 0 8 0 16 0 0 0 0 8 8 0 0 0 8 % I
% Lys: 8 0 0 0 0 0 0 0 0 8 0 8 0 0 0 % K
% Leu: 16 16 8 8 8 16 8 8 54 8 47 0 0 0 8 % L
% Met: 54 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 8 16 0 0 0 0 16 0 0 0 0 % N
% Pro: 0 16 8 0 0 0 0 0 8 0 0 0 16 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 16 8 0 0 8 % Q
% Arg: 0 8 8 8 8 47 0 0 0 8 0 8 0 24 0 % R
% Ser: 0 0 8 8 8 16 24 47 8 0 0 0 0 0 8 % S
% Thr: 0 0 0 0 0 0 0 8 0 0 0 0 8 8 0 % T
% Val: 16 47 0 8 0 0 0 8 0 16 8 62 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _