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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FGF22 All Species: 25.45
Human Site: T49 Identified Species: 62.22
UniProt: Q9HCT0 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCT0 NP_065688.1 170 19663 T49 W R R L F S S T H F F L R V D
Chimpanzee Pan troglodytes XP_524019 195 22108 L74 H Q G M P R S L A V V L V L A
Rhesus Macaque Macaca mulatta XP_001091268 170 19708 T49 W R R L F S S T H F F L R V D
Dog Lupus familis XP_855276 224 24759 T102 W R K L F S F T K Y F L K I E
Cat Felis silvestris
Mouse Mus musculus Q9ESS2 162 18908 T40 W R R L F S S T H F F L R V D
Rat Rattus norvegicus P70492 215 24011 T93 W R K L F S F T K Y F L K I E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518820 193 21965 F72 P R Y I L F P F C F T G P K V
Chicken Gallus gallus P48801 220 25031 T53 R R K L Y C A T K Y H L Q I H
Frog Xenopus laevis Q91875 209 23644 T71 R R Q L Y C R T G F H L E I F
Zebra Danio Brachydanio rerio P48802 256 28905 T70 R R K L Y C A T K Y H L Q I H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 62.5 94.7 40.1 N.A. 81.7 41.8 N.A. 42.4 35.4 35.4 32.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 67.6 95.8 58.4 N.A. 86.4 61.4 N.A. 53.8 51.3 51.2 40.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 100 53.3 N.A. 100 53.3 N.A. 13.3 26.6 33.3 26.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 33.3 100 86.6 N.A. 100 86.6 N.A. 20 66.6 53.3 66.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 20 0 10 0 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 30 0 0 10 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 30 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 20 % E
% Phe: 0 0 0 0 50 10 20 10 0 50 50 0 0 0 10 % F
% Gly: 0 0 10 0 0 0 0 0 10 0 0 10 0 0 0 % G
% His: 10 0 0 0 0 0 0 0 30 0 30 0 0 0 20 % H
% Ile: 0 0 0 10 0 0 0 0 0 0 0 0 0 50 0 % I
% Lys: 0 0 40 0 0 0 0 0 40 0 0 0 20 10 0 % K
% Leu: 0 0 0 80 10 0 0 10 0 0 0 90 0 10 0 % L
% Met: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 0 0 0 10 0 10 0 0 0 0 0 10 0 0 % P
% Gln: 0 10 10 0 0 0 0 0 0 0 0 0 20 0 0 % Q
% Arg: 30 90 30 0 0 10 10 0 0 0 0 0 30 0 0 % R
% Ser: 0 0 0 0 0 50 40 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 80 0 0 10 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 10 10 0 10 30 10 % V
% Trp: 50 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 30 0 0 0 0 40 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _