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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PREB All Species: 27.27
Human Site: S297 Identified Species: 60
UniProt: Q9HCU5 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCU5 NP_037520.1 417 45468 S297 F L P L R T K S C G H E V V S
Chimpanzee Pan troglodytes XP_515352 493 54100 S373 F L P L R T K S C G H E V V S
Rhesus Macaque Macaca mulatta XP_001088763 519 57081 S399 F L P L R T K S C G H E V I S
Dog Lupus familis XP_540122 418 45950 S298 F L P L R T K S C G H E V I S
Cat Felis silvestris
Mouse Mus musculus Q9WUQ2 417 45419 S297 F L P L R T R S C G H E V I S
Rat Rattus norvegicus Q9WTV0 417 45339 S297 F L P L Q T R S C G H E V I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515477 474 50907 P355 L P T P H D T P Y R Y Q A C R
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393821 432 48337 P315 G N I V K A I P Y K E T L S A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786066 442 49178 C323 F T I D K T V C T G D D I L S
Poplar Tree Populus trichocarpa XP_002314804 370 40241 F252 P K E N D E I F A S C R F S Q
Maize Zea mays NP_001169106 417 45353 S297 F L P L Q T R S C G H E V I S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.7 77.8 92.8 N.A. 88.7 89.4 N.A. 54.6 N.A. N.A. N.A. N.A. N.A. 32.1 N.A. 32.3
Protein Similarity: 100 82.9 79 95.2 N.A. 93.5 94.2 N.A. 63.9 N.A. N.A. N.A. N.A. N.A. 53.4 N.A. 52.4
P-Site Identity: 100 100 93.3 93.3 N.A. 86.6 80 N.A. 0 N.A. N.A. N.A. N.A. N.A. 0 N.A. 26.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 N.A. N.A. N.A. N.A. N.A. 26.6 N.A. 53.3
Percent
Protein Identity: 23.7 89.6 N.A. N.A. N.A. N.A.
Protein Similarity: 38.1 94.2 N.A. N.A. N.A. N.A.
P-Site Identity: 0 80 N.A. N.A. N.A. N.A.
P-Site Similarity: 0 100 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 0 0 10 0 0 0 10 0 10 % A
% Cys: 0 0 0 0 0 0 0 10 64 0 10 0 0 10 0 % C
% Asp: 0 0 0 10 10 10 0 0 0 0 10 10 0 0 0 % D
% Glu: 0 0 10 0 0 10 0 0 0 0 10 64 0 0 0 % E
% Phe: 73 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % F
% Gly: 10 0 0 0 0 0 0 0 0 73 0 0 0 0 0 % G
% His: 0 0 0 0 10 0 0 0 0 0 64 0 0 0 0 % H
% Ile: 0 0 19 0 0 0 19 0 0 0 0 0 10 46 0 % I
% Lys: 0 10 0 0 19 0 37 0 0 10 0 0 0 0 0 % K
% Leu: 10 64 0 64 0 0 0 0 0 0 0 0 10 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 10 64 10 0 0 0 19 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 19 0 0 0 0 0 0 10 0 0 10 % Q
% Arg: 0 0 0 0 46 0 28 0 0 10 0 10 0 0 10 % R
% Ser: 0 0 0 0 0 0 0 64 0 10 0 0 0 19 73 % S
% Thr: 0 10 10 0 0 73 10 0 10 0 0 10 0 0 0 % T
% Val: 0 0 0 10 0 0 10 0 0 0 0 0 64 19 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 19 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _