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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PREB All Species: 30.91
Human Site: S60 Identified Species: 68
UniProt: Q9HCU5 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCU5 NP_037520.1 417 45468 S60 I N G R L S A S L L H S H D T
Chimpanzee Pan troglodytes XP_515352 493 54100 S136 I N G R L S A S L L H S H D T
Rhesus Macaque Macaca mulatta XP_001088763 519 57081 S160 I N G R L S A S L L H S H D T
Dog Lupus familis XP_540122 418 45950 S60 I N G R L S A S L L H S H D T
Cat Felis silvestris
Mouse Mus musculus Q9WUQ2 417 45419 S60 I N G C L S A S L L H S H D T
Rat Rattus norvegicus Q9WTV0 417 45339 S60 I S G C L S A S L L H S H D T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515477 474 50907 S157 I D G R L S A S L L H S H D T
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393821 432 48337 C95 A A G Q E S H C Q L Y N V S S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786066 442 49178 A70 D N G D D Q S A I M N A A L R
Poplar Tree Populus trichocarpa XP_002314804 370 40241 E54 Q E Q Q Q E E E E E I P K P S
Maize Zea mays NP_001169106 417 45353 S60 I S G C L S A S L L H S H D T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.7 77.8 92.8 N.A. 88.7 89.4 N.A. 54.6 N.A. N.A. N.A. N.A. N.A. 32.1 N.A. 32.3
Protein Similarity: 100 82.9 79 95.2 N.A. 93.5 94.2 N.A. 63.9 N.A. N.A. N.A. N.A. N.A. 53.4 N.A. 52.4
P-Site Identity: 100 100 100 100 N.A. 93.3 86.6 N.A. 93.3 N.A. N.A. N.A. N.A. N.A. 20 N.A. 13.3
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 100 N.A. N.A. N.A. N.A. N.A. 46.6 N.A. 53.3
Percent
Protein Identity: 23.7 89.6 N.A. N.A. N.A. N.A.
Protein Similarity: 38.1 94.2 N.A. N.A. N.A. N.A.
P-Site Identity: 0 86.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 13.3 93.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 0 0 0 73 10 0 0 0 10 10 0 0 % A
% Cys: 0 0 0 28 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 10 10 0 10 10 0 0 0 0 0 0 0 0 73 0 % D
% Glu: 0 10 0 0 10 10 10 10 10 10 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 91 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 10 0 0 0 73 0 73 0 0 % H
% Ile: 73 0 0 0 0 0 0 0 10 0 10 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % K
% Leu: 0 0 0 0 73 0 0 0 73 82 0 0 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 0 55 0 0 0 0 0 0 0 0 10 10 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 10 0 10 0 % P
% Gln: 10 0 10 19 10 10 0 0 10 0 0 0 0 0 0 % Q
% Arg: 0 0 0 46 0 0 0 0 0 0 0 0 0 0 10 % R
% Ser: 0 19 0 0 0 82 10 73 0 0 0 73 0 10 19 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 73 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _