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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PREB All Species: 18.48
Human Site: Y17 Identified Species: 40.67
UniProt: Q9HCU5 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCU5 NP_037520.1 417 45468 Y17 Y R A P F P L Y A L Q V D P S
Chimpanzee Pan troglodytes XP_515352 493 54100 F93 G A E L R L G F L L V V D P S
Rhesus Macaque Macaca mulatta XP_001088763 519 57081 C117 A L E L N L G C P R V V D P S
Dog Lupus familis XP_540122 418 45950 Y17 Y R A P F P L Y A L Q V D P S
Cat Felis silvestris
Mouse Mus musculus Q9WUQ2 417 45419 Y17 Y R A P F P L Y A L R I D P K
Rat Rattus norvegicus Q9WTV0 417 45339 Y17 Y R A P F P L Y A L R I D P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515477 474 50907 V105 R R L S H P N V P S C G R P P
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393821 432 48337 L18 L A K V N F P L Y T L Q M L T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786066 442 49178 G30 F L V A G G G G E S K T G V P
Poplar Tree Populus trichocarpa XP_002314804 370 40241 Y15 D P Q S L Q K Y G V P L Y S A
Maize Zea mays NP_001169106 417 45353 Y17 Y R A P F P L Y A L R I D P K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.7 77.8 92.8 N.A. 88.7 89.4 N.A. 54.6 N.A. N.A. N.A. N.A. N.A. 32.1 N.A. 32.3
Protein Similarity: 100 82.9 79 95.2 N.A. 93.5 94.2 N.A. 63.9 N.A. N.A. N.A. N.A. N.A. 53.4 N.A. 52.4
P-Site Identity: 100 33.3 26.6 100 N.A. 80 80 N.A. 20 N.A. N.A. N.A. N.A. N.A. 0 N.A. 0
P-Site Similarity: 100 40 26.6 100 N.A. 93.3 93.3 N.A. 20 N.A. N.A. N.A. N.A. N.A. 6.6 N.A. 13.3
Percent
Protein Identity: 23.7 89.6 N.A. N.A. N.A. N.A.
Protein Similarity: 38.1 94.2 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 80 N.A. N.A. N.A. N.A.
P-Site Similarity: 26.6 93.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 19 46 10 0 0 0 0 46 0 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 10 0 0 0 0 % C
% Asp: 10 0 0 0 0 0 0 0 0 0 0 0 64 0 0 % D
% Glu: 0 0 19 0 0 0 0 0 10 0 0 0 0 0 0 % E
% Phe: 10 0 0 0 46 10 0 10 0 0 0 0 0 0 0 % F
% Gly: 10 0 0 0 10 10 28 10 10 0 0 10 10 0 0 % G
% His: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 28 0 0 0 % I
% Lys: 0 0 10 0 0 0 10 0 0 0 10 0 0 0 28 % K
% Leu: 10 19 10 19 10 19 46 10 10 55 10 10 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 19 0 10 0 0 0 0 0 0 0 0 % N
% Pro: 0 10 0 46 0 55 10 0 19 0 10 0 0 73 19 % P
% Gln: 0 0 10 0 0 10 0 0 0 0 19 10 0 0 0 % Q
% Arg: 10 55 0 0 10 0 0 0 0 10 28 0 10 0 0 % R
% Ser: 0 0 0 19 0 0 0 0 0 19 0 0 0 10 37 % S
% Thr: 0 0 0 0 0 0 0 0 0 10 0 10 0 0 10 % T
% Val: 0 0 10 10 0 0 0 10 0 10 19 37 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 46 0 0 0 0 0 0 55 10 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _