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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TXNRD2 All Species: 23.94
Human Site: S282 Identified Species: 35.11
UniProt: Q9NNW7 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NNW7 NP_006431.2 524 56507 S282 F L R G C A P S R V R R L P D
Chimpanzee Pan troglodytes XP_001166615 481 51948 L252 I M M R S I P L R G F D Q Q M
Rhesus Macaque Macaca mulatta NP_001152971 524 56314 S282 F L R G C A P S R V R R L P D
Dog Lupus familis XP_850181 509 55065 S269 F L R G C T P S R V R R L P D
Cat Felis silvestris
Mouse Mus musculus Q9JLT4 524 56434 S282 F L K G C V P S H I K K L P T
Rat Rattus norvegicus Q9Z0J5 526 56406 S284 F L K G C V P S L I R K L P T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001116163 518 56137 A276 F L K K C V P A K V E K L E S
Frog Xenopus laevis NP_001080052 504 54666 S262 F L W K C T P S H V E K L K N
Zebra Danio Brachydanio rerio NP_898895 602 65949 T357 F L R K F V P T K I E Q L E A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91938 596 64304 L356 F L R K T V P L S V E K Q D D
Honey Bee Apis mellifera NP_001171496 537 59227 S297 F I Y E A K P S K I E K Q A D
Nematode Worm Caenorhab. elegans Q17745 667 74094 R415 F E A G V P T R I E Q I D E K
Sea Urchin Strong. purpuratus XP_797733 490 53044 E253 F L W Q Q V P E S V A K N Q N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P48641 499 53852 N260 N L E G R G V N L H P Q T S L
Baker's Yeast Sacchar. cerevisiae P41921 483 53422 N242 K F D E C I Q N T I T D H Y V
Red Bread Mold Neurospora crassa Q873E8 468 50294 L241 K V H K K S Q L T S V Q K D A
Conservation
Percent
Protein Identity: 100 91 98.2 83.2 N.A. 84.5 82.6 N.A. N.A. 72.9 68.6 47 N.A. 48.9 53 40.7 55.7
Protein Similarity: 100 91.2 99 91.4 N.A. 91.5 90.8 N.A. N.A. 86 82.2 62.2 N.A. 62.4 68.5 56.2 69.8
P-Site Identity: 100 13.3 100 93.3 N.A. 53.3 60 N.A. N.A. 40 46.6 33.3 N.A. 40 26.6 13.3 26.6
P-Site Similarity: 100 20 100 93.3 N.A. 80 80 N.A. N.A. 66.6 60 60 N.A. 46.6 53.3 20 40
Percent
Protein Identity: N.A. N.A. N.A. 33.7 32.8 34.7
Protein Similarity: N.A. N.A. N.A. 51.7 53 52.4
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 0
P-Site Similarity: N.A. N.A. N.A. 26.6 20 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 7 13 0 7 0 0 7 0 0 7 13 % A
% Cys: 0 0 0 0 50 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 0 0 0 0 0 0 0 13 7 13 32 % D
% Glu: 0 7 7 13 0 0 0 7 0 7 32 0 0 19 0 % E
% Phe: 75 7 0 0 7 0 0 0 0 0 7 0 0 0 0 % F
% Gly: 0 0 0 44 0 7 0 0 0 7 0 0 0 0 0 % G
% His: 0 0 7 0 0 0 0 0 13 7 0 0 7 0 0 % H
% Ile: 7 7 0 0 0 13 0 0 7 32 0 7 0 0 0 % I
% Lys: 13 0 19 32 7 7 0 0 19 0 7 44 7 7 7 % K
% Leu: 0 69 0 0 0 0 0 19 13 0 0 0 50 0 7 % L
% Met: 0 7 7 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 7 0 0 0 0 0 0 13 0 0 0 0 7 0 13 % N
% Pro: 0 0 0 0 0 7 75 0 0 0 7 0 0 32 0 % P
% Gln: 0 0 0 7 7 0 13 0 0 0 7 19 19 13 0 % Q
% Arg: 0 0 32 7 7 0 0 7 25 0 25 19 0 0 0 % R
% Ser: 0 0 0 0 7 7 0 44 13 7 0 0 0 7 7 % S
% Thr: 0 0 0 0 7 13 7 7 13 0 7 0 7 0 13 % T
% Val: 0 7 0 0 7 38 7 0 0 44 7 0 0 0 7 % V
% Trp: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 0 0 0 0 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _