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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCB6 All Species: 17.27
Human Site: Y214 Identified Species: 31.67
UniProt: Q9NP58 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NP58 NP_005680.1 842 93886 Y214 P G L R P Q S Y T L Q V H E E
Chimpanzee Pan troglodytes XP_001161097 843 94009 Y214 P G L R P Q S Y T L Q V H E E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536073 1099 120564 Y473 P G L R P Q S Y A L K V N E E
Cat Felis silvestris
Mouse Mus musculus Q9DC29 842 93752 Y214 P G L R P Q S Y T L H V H E E
Rat Rattus norvegicus O70595 836 93286 Y214 P G L R P Q S Y T L H V N E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001139165 800 90747 L206 P R R P Y M L L V N E D E R D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650503 866 97867 P200 K A P G I M A P Y N P H Q R L
Honey Bee Apis mellifera XP_001122583 748 85114 C169 L Q L R V I F C F G L L I S G
Nematode Worm Caenorhab. elegans NP_001022812 801 90557 A200 G C S S R E S A W N N L S K K
Sea Urchin Strong. purpuratus XP_001181861 832 94582 M202 G L P R K S Y M L I V N E D G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LVM1 728 80402 F149 R V I A A L G F L V G A K V L
Baker's Yeast Sacchar. cerevisiae P40416 690 77504 V111 N N K V R I R V L I A L G L L
Red Bread Mold Neurospora crassa Q7RX59 716 78739 L137 L L V G G K V L N V Q V P F Y
Conservation
Percent
Protein Identity: 100 99.5 N.A. 67.7 N.A. 88.9 87.4 N.A. N.A. N.A. N.A. 61.7 N.A. 49.5 50 42.5 51.3
Protein Similarity: 100 99.6 N.A. 71.5 N.A. 93.4 92.9 N.A. N.A. N.A. N.A. 74.9 N.A. 64.7 65.9 59.1 66.2
P-Site Identity: 100 100 N.A. 80 N.A. 93.3 86.6 N.A. N.A. N.A. N.A. 6.6 N.A. 0 13.3 6.6 6.6
P-Site Similarity: 100 100 N.A. 93.3 N.A. 93.3 93.3 N.A. N.A. N.A. N.A. 20 N.A. 6.6 20 33.3 20
Percent
Protein Identity: N.A. N.A. N.A. 36.3 33 35.2
Protein Similarity: N.A. N.A. N.A. 52.4 49.5 51.5
P-Site Identity: N.A. N.A. N.A. 0 0 13.3
P-Site Similarity: N.A. N.A. N.A. 20 13.3 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 8 8 0 8 8 8 0 8 8 0 0 0 % A
% Cys: 0 8 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 8 0 8 8 % D
% Glu: 0 0 0 0 0 8 0 0 0 0 8 0 16 39 39 % E
% Phe: 0 0 0 0 0 0 8 8 8 0 0 0 0 8 0 % F
% Gly: 16 39 0 16 8 0 8 0 0 8 8 0 8 0 16 % G
% His: 0 0 0 0 0 0 0 0 0 0 16 8 24 0 0 % H
% Ile: 0 0 8 0 8 16 0 0 0 16 0 0 8 0 0 % I
% Lys: 8 0 8 0 8 8 0 0 0 0 8 0 8 8 8 % K
% Leu: 16 16 47 0 0 8 8 16 24 39 8 24 0 8 24 % L
% Met: 0 0 0 0 0 16 0 8 0 0 0 0 0 0 0 % M
% Asn: 8 8 0 0 0 0 0 0 8 24 8 8 16 0 0 % N
% Pro: 47 0 16 8 39 0 0 8 0 0 8 0 8 0 0 % P
% Gln: 0 8 0 0 0 39 0 0 0 0 24 0 8 0 0 % Q
% Arg: 8 8 8 54 16 0 8 0 0 0 0 0 0 16 0 % R
% Ser: 0 0 8 8 0 8 47 0 0 0 0 0 8 8 0 % S
% Thr: 0 0 0 0 0 0 0 0 31 0 0 0 0 0 0 % T
% Val: 0 8 8 8 8 0 8 8 8 16 8 47 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 8 39 8 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _