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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA8
All Species:
14.24
Human Site:
S248
Identified Species:
34.81
UniProt:
Q9NP80
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NP80
NP_056538.1
782
88477
S248
V
E
E
G
K
L
R
S
P
D
P
G
I
L
A
Chimpanzee
Pan troglodytes
XP_001166265
782
88516
S248
V
E
E
G
K
L
R
S
P
D
P
D
I
L
A
Rhesus Macaque
Macaca mulatta
XP_001096331
782
88385
S248
V
E
E
G
K
L
S
S
P
D
P
G
I
L
A
Dog
Lupus familis
XP_848649
784
88284
S249
V
E
E
E
K
A
S
S
P
D
P
G
I
L
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8K1N1
776
87363
A248
S
P
G
P
D
T
V
A
D
R
P
D
S
E
S
Rat
Rattus norvegicus
NP_001101490
400
45630
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001124209
803
90680
T269
T
V
I
S
E
E
K
T
V
N
S
A
A
A
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001918731
696
76918
R187
S
S
V
P
I
S
P
R
K
G
I
S
H
Y
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500969
546
60511
N37
R
P
F
F
S
S
S
N
T
Q
G
G
A
S
A
Sea Urchin
Strong. purpuratus
XP_782958
927
103360
S363
N
L
E
N
P
H
T
S
V
E
Y
K
T
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.6
89.6
N.A.
82.3
37.4
N.A.
N.A.
60.1
N.A.
47.8
N.A.
N.A.
N.A.
29.4
32.9
Protein Similarity:
100
99.8
98.5
94.6
N.A.
90.6
43.3
N.A.
N.A.
73.5
N.A.
63.8
N.A.
N.A.
N.A.
43.7
51.2
P-Site Identity:
100
93.3
93.3
73.3
N.A.
6.6
0
N.A.
N.A.
0
N.A.
0
N.A.
N.A.
N.A.
13.3
13.3
P-Site Similarity:
100
93.3
93.3
73.3
N.A.
20
0
N.A.
N.A.
26.6
N.A.
0
N.A.
N.A.
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
10
0
0
0
10
20
10
40
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
0
10
40
0
20
0
10
0
% D
% Glu:
0
40
50
10
10
10
0
0
0
10
0
0
0
10
0
% E
% Phe:
0
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
30
0
0
0
0
0
10
10
40
0
0
0
% G
% His:
0
0
0
0
0
10
0
0
0
0
0
0
10
0
0
% H
% Ile:
0
0
10
0
10
0
0
0
0
0
10
0
40
0
10
% I
% Lys:
0
0
0
0
40
0
10
0
10
0
0
10
0
0
0
% K
% Leu:
0
10
0
0
0
30
0
0
0
0
0
0
0
40
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
10
0
0
0
10
0
10
0
0
0
0
0
% N
% Pro:
0
20
0
20
10
0
10
0
40
0
50
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% Q
% Arg:
10
0
0
0
0
0
20
10
0
10
0
0
0
0
0
% R
% Ser:
20
10
0
10
10
20
30
50
0
0
10
10
10
10
20
% S
% Thr:
10
0
0
0
0
10
10
10
10
0
0
0
10
0
0
% T
% Val:
40
10
10
0
0
0
10
0
20
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _